Wound healing is a complex sequence of tissue protection, replacement, and reorganization leading to regenerated tissue. Disruption of any of these steps results in the process being incomplete as an ulcer or over-exuberant as a hypertrophic scar. Over the past decade, it has become evident that the extracellular matrix and associated components orchestrate this process. However, the cellular events that are induced by the extracellular matrix to accomplish wound healing remain to be defined. Herein we propose that matrix-regulated cellular macro-autophagy is key to both the tissue replacement and resolution stages of healing by directing cellular function or apoptosis. Further, disruptions in matrix turnover alter autophagic function leading to chronic wounds or scarring. While the literature that directly investigates autophagy during wound healing is sparse, the emerging picture supports our proposing a model of the centrality of the matrix-autophagy modulation as central to physiologic and pathologic healing.

伤口愈合是导致组织再生的组织保护、替换和重组的复杂序列。任何这些步骤的中断都会导致该过程不完整，如溃疡或过度旺盛，如肥厚性疤痕。在过去的十年中，很明显，细胞外基质和相关成分协调了这一过程。然而，由细胞外基质诱导以完成伤口愈合的细胞事件仍有待确定。在这里，我们提出基质调节的细胞巨自噬通过指导细胞功能或细胞凋亡是组织替代和愈合阶段的关键。此外，基质周转的中断会改变自噬功能，导致慢性伤口或疤痕。