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Self-dispersible fluorescent probe with aggregation-induced emission feature for sequence detection of Fe3+ and Ca2+
Colloid and Interface Science Communications ( IF 4.5 ) Pub Date : 2021-01-05 , DOI: 10.1016/j.colcom.2020.100358
Deqiang Wang , Chong Ma , Xin Zhou , Wei Long , Meiying Liu , Xiaoyong Zhang , Yen Wei

In this work, the amphiphilic molecule (called as DEBA) with aggregation-induced emission (AIE) feature was synthesized using hydrophobic tetraphenylethylene (TPE) as chromophore and hydrophilic 2-methylaminopyridine to bind with metal ions. The probe could self-assemble in aqueous solution and shows obvious enhanced fluorescence intensity and good water dispersibility. We demonstrated that DEBA could be utilized for selective and highly sensitive “turn-off” detection of Fe3+. Moreover, the fluorescence of probe-Fe3+ complex could restore after adding of Ca2+ and be utilized for “turn-on” detection of Ca2+. The detection limit of probe towards Fe3+ is 2.69 × 10−9 M. To evaluate the potential utilization of probe for sensing Fe3+ and Ca2+ in living organisms, cell viability and CLSM imaging of probe were also examined. The results demonstrated that the probe possesses excellent water dispersibility, low cytotoxicity and could be utilized for sequence detection of Fe3+ and Ca2+ in both aqueous solution and living cells.



中文翻译:

具有聚集诱导发射特征的自分散荧光探针,用于Fe 3+和Ca 2+的序列检测

在这项工作中,使用疏水性四苯基乙烯(TPE)作为生色团和亲水性2-甲基氨基吡啶与金属离子结合,合成了具有聚集诱导发射(AIE)特征的两亲分子(DEBA)。该探针可在水溶液中自组装,并显示出明显增强的荧光强度和良好的水分散性。我们证明DEBA可用于Fe 3+的选择性和高灵敏度“关断”检测。此外,探针-Fe 3+配合物的荧光可以在添加Ca 2+后恢复,并用于“开启”检测Ca 2+。探针对Fe 3+的检出限为2.69×10 -9 M.为了评估探针在活生物体中检测Fe 3+和Ca 2+的潜在利用,还检查了探针的细胞活力和CLSM成像。结果表明,该探针具有良好的水分散性,细胞毒性低,可用于水溶液和活细胞中Fe 3+和Ca 2+的序列检测。

更新日期:2021-01-06
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