OBJECTIVE Choroid plexus tumours (CPT) are rare intraventricular tumours representing less than 0.5 % of brain tumours. The tumour is commonly located in the supratentorial region, but the location varies depending on the age. We present our experience of managing these tumours in a tertiary hospital. METHODS Retrospectively, we reviewed our operative database and recruited 80 cases of CPT who underwent surgical treatment in our institute from 1995 to 2018. We analysed the factors affecting the outcome and the perioperative complications of the choroid plexus tumour. RESULTS A total of 80 choroid plexus tumours were recruited in our retrospective review, of which 44 were choroid plexus papilloma (CPP), 13 were atypical choroid plexus tumours (ACPP), 23 were choroid plexus carcinomas (CPC). The mean age was 16.75 (SD 16.71) in the overall cohort. Males were found to be predominant in all tumour groups (M/F: 46/34). Headache was the most common symptom (52.5 %). Hydrocephalus was seen in 53.8 % of cases. The median overall survival was 89.88 months. Gross total resection was achieved in 62.5 % cases (n = 50/80), and near-total resection in 27. 5 % cases (n = 22/80). The median overall survival was 89.88 months. The median overall survival for CPP, ACPP, CPC was 106.83, 37.37, 36.19 months, respectively. Median Event-free survival was 65.83 months. A Cox regression analysis of predictors of overall survival of atypical CPP and CPC was done, in which age, sex, location, size, the extent of the resection, and complications were considered. The extent of the resection (p = 0.01) and the size (p = 0.02) were related to overall survival CONCLUSION: CPT's are the rare intraventricular tumours, which requires aggressive resection strategies. The extent of resection offers survival benefit based on the histological grades.

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脉络丛肿瘤的管理：来自三级医院的综合研究

目的 脉络丛肿瘤 (CPT) 是罕见的脑室内肿瘤，占脑肿瘤的 0.5% 以下。肿瘤通常位于幕上区域，但位置因年龄而异。我们介绍了我们在三级医院管理这些肿瘤的经验。方法回顾性地回顾了我们的手术数据库，招募了80例1995年至2018年在我院接受手术治疗的CPT患者，分析影响脉络丛肿瘤预后和围手术期并发症的因素。结果 我们的回顾性研究共招募了 80 例脉络丛肿瘤，其中 44 例为脉络丛乳头状瘤（CPP），13 例为非典型脉络丛肿瘤（ACPP），23 例为脉络丛癌（CPC）。整个队列的平均年龄为 16.75 (SD 16.71)。发现男性在所有肿瘤组中占主导地位（男/女：46/34）。头痛是最常见的症状（52.5%）。53.8% 的病例出现脑积水。中位总生存期为 89.88 个月。62.5 % 的病例（n = 50/80）实现了大体完全切除，27. 5 % 的病例（n = 22/80）实现了接近完全切除。中位总生存期为 89.88 个月。CPP、ACPP、CPC 的中位总生存期分别为 106.83、37.37、36.19 个月。中位无事件生存期为 65.83 个月。对非典型 CPP 和 CPC 的总生存预测因子进行 Cox 回归分析，其中考虑了年龄、性别、位置、大小、切除范围和并发症。切除的范围 (p = 0.01) 和大小 (p = 0.02) 与总生存期相关 结论：CPT 是罕见的脑室内肿瘤，这需要积极的切除策略。根据组织学分级，切除范围提供生存益处。