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Relationship between brain AD biomarkers and episodic memory performance in healthy aging
Brain and Cognition ( IF 2.5 ) Pub Date : 2021-01-06 , DOI: 10.1016/j.bandc.2020.105680
Lou Rizzolo , Justinas Narbutas , Maxime Van Egroo , Daphne Chylinski , Gabriel Besson , Marion Baillet , Mohamed Ali Bahri , Eric Salmon , Pierre Maquet , Gilles Vandewalle , Christine Bastin , Fabienne Collette

The presence of brain biomarkers can be observed decades before the first clinical symptoms of Alzheimer’s disease (AD). We aimed to determine whether associations between biomarkers and episodic memory performance already exist in a healthy late middle-aged population or only in participants over 60 years old. Performance at the Free and Cued Selective Reminding Test [FCSRT], the Logical Memory test and the Mnemonic Similarity Task [MST] was determined in sixty healthy participants (50–70 y.) with a negative status for amyloid-beta (Aβ) biomarker. We assessed Aβ cortical level and tau/neuroinflammation burden using PET scanner, and hippocampal atrophy with MRI scanner. Generalized linear mixed models showed that MST scores (recognition and pattern separation) were positively associated with hippocampal volume in participants over 60 years. No association between memory performance and Aβ and tau/neuroinflammation burden was found in the older or in the younger age group. This suggests that visual recognition memory and discrimination of lures may constitute early cognitive markers of memory decline in an older population.



中文翻译:

健康衰老中脑AD生物标志物与情景记忆表现的关系

可以在阿尔茨海默氏病(AD)的第一个临床症状出现几十年之前观察到脑生物标志物的存在。我们旨在确定在健康的中年晚期人群中或仅在60岁以上的参与者中是否已经存在生物标志物与情景记忆表现之间的关联。在六十名健康参与者(50-70岁)中确定了淀粉样蛋白-β(Aβ)生物标志物的阴性状态,进行了自由和暗示的选择性提醒测试[FCSRT],逻辑记忆力测试和记忆相似任务[MST]的表现。我们使用PET扫描仪评估Aβ皮质水平和tau /神经炎症负担,并使用MRI扫描仪评估海马萎缩。广义线性混合模型显示60多年来参与者的MST得分(识别和模式分离)与海马体积呈正相关。在年龄较大或较年轻的年龄组中,记忆力与Aβ和tau /神经炎症负担之间没有关联。这表明视觉识别记忆和诱饵的辨别可能构成老年人群记忆衰退的早期认知标志。

更新日期:2021-01-06
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