This study aimed to evaluate the effect of daily sublethal doses of aluminum (Al) on hematological, physiological, biochemical, and behavioral changes in male albino Wistar rats. In addition, Al tissue accumulation and histopathological changes in the cerebral cortex, liver, and kidney were examined. The rats were randomly separated into three groups. Group 1 included rats who received the median deadly dose (LD₅₀) of aluminum chloride (AlCl₃), group 2 served as the control, and group 3 was treated with a non-lethal dose of AlCl₃ (1.5 mg/kg) intraperitoneally for 45 days. At defined time intervals, hepatic and renal specific enzymes and biochemical activity were measured. In addition, we examined Al accumulation, the condition of the liver via histological methods, and the impact on the cerebral cortex. In comparison to the controls, rats treated with AlCl₃ exhibited a rise in AST, ALT, and ALP enzyme activity. We also saw a significant decrease in body weight and a decrease in total protein, lipids, cholesterol, acetylcholinesterase (AChE), RBCs, and Hb levels compared to the control group. Histopathological examination suggested severe changes in the liver, kidney, and cerebral cortex of the rats. The current study indicates that sublethal daily exposure to AlCl₃ causes hazardous effects, as increased Al concentration in the body is shown to induce detrimental biochemical and histological changes as well as decreased body weight. Therefore, careful attention should be given to treatments requiring long exposure in patients and the potential for accumulation via food and drinking.

本研究旨在评估每日亚致死剂量铝 (Al) 对雄性白化 ​​Wistar 大鼠血液学、生理学、生化和行为变化的影响。此外，还检查了大脑皮层、肝脏和肾脏中的 Al 组织积累和组织病理学变化。将大鼠随机分成三组。第 1 组包括接受中位致死剂量 (LD ₅₀ ) 氯化铝 (AlCl ₃ ) 的大鼠，第 2 组作为对照组，第 3 组接受非致死剂量的 AlCl _{3 治疗}(1.5 mg/kg) 腹腔注射 45 天。在规定的时间间隔内，测量肝和肾特异性酶和生化活性。此外，我们通过组织学方法检查了铝的积累、肝脏的状况以及对大脑皮层的影响。与对照组相比，用 AlCl ₃处理的大鼠表现出 AST、ALT 和 ALP 酶活性的升高。与对照组相比，我们还看到体重显着下降，总蛋白质、脂质、胆固醇、乙酰胆碱酯酶 (AChE)、红细胞和 Hb 水平下降。组织病理学检查表明大鼠的肝脏、肾脏和大脑皮层发生了严重变化。目前的研究表明，每日亚致死量暴露于 AlCl ₃会导致有害影响，因为体内铝浓度的增加会导致有害的生化和组织学变化以及体重下降。因此，应仔细注意需要患者长期接触的治疗以及通过食物和饮水积累的可能性。