Collagen (Col) from marine organisms has been emerging as an important alternative for commercial Col and it has been considered highly attractive by the industry. Despite the positive effects of Col from marine origin, there is still limited understanding of the effects of this natural biomaterial in the process of wound healing in animal studies. In this context, the purpose of this study was to perform a systematic review of the literature to examine the effects of Col from different marine species in the process of skin tissue healing using experimental models of skin wound. The search was carried out according to the orientations of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), and the descriptors of the Medical Subject Headings (MeSH) were defined: “marine collagen,” “spongin,” “spongin,” “skin,” and “wound.” A total of 42 articles were retrieved from the databases PubMed and Scopus. After the eligibility analyses, this review covers the different marine sources of Col reported in 10 different papers from the beginning of 2011 through the middle of 2019. The results were based mainly on histological analysis and it demonstrated that Col-based treatment resulted in a higher deposition of granulation tissue, stimulation of re-epitalization and neoangiogenesis and increased amount of Col of the wound, culminating in a more mature morphological aspect. In conclusion, this review demonstrates that marine Col from different species presented positive effects on the process of wound skin healing in experimental models used, demonstrating the huge potential of this biomaterial for tissue engineering proposals.

来自海洋生物的胶原蛋白 (Col) 已成为商业 Col 的重要替代品，并且被业界认为极具吸引力。尽管来自海洋的 Col 具有积极作用，但对这种天然生物材料在动物研究中伤口愈合过程中的作用的了解仍然有限。在这种情况下，本研究的目的是对文献进行系统回顾，以使用皮肤伤口实验模型检查来自不同海洋物种的 Col 在皮肤组织愈合过程中的影响。根据系统评价和元分析首选报告项目 (PRISMA) 的方向进行检索，医学主题词 (MeSH) 的描述词定义为：“海洋胶原蛋白”、“海绵”、“海绵” ”“皮肤”和“伤口”。从 PubMed 和 Scopus 数据库中总共检索到 42 篇文章。经过资格分析，本综述涵盖了 2011 年初至 2019 年中 10 篇不同论文中报道的 Col 的不同海洋来源。 结果主要基于组织学分析，表明基于 Col 的处理导致更高的肉芽组织的沉积，刺激再上皮和新血管生成以及伤口的 Col 量增加，最终形成更成熟的形态学方面。总之，本综述表明，来自不同物种的海洋 Col 在所使用的实验模型中对伤口皮肤愈合过程产生了积极影响，证明了这种生物材料在组织工程提案中的巨大潜力。