Purpose

Evaluating the potential of gross Linum usitatissimum L. seed mucilage to be used as a drug release retardant. In order to do so, seeds were subjected to a simple and scalable extractive process comprising few stages, without alcohol-based precipitation. Matrix tablets based on hydrophilic polymers are one of the simplest forms of developing modified release systems.

Methods

Flaxseeds were added to distilled water at a flaxseed:water ratio of 1:13; the suspension was continuously stirred at room temperature, for 24 h. Flaxseeds were sieved and the gross linseed mucilage was freeze-dried. Subsequently, the sample was analyzed through Fourier transform infrared spectroscopy (IV-TF) at wavelength ranging from 650 to 4000 cm⁻¹.

Results

Infrared (IR) spectroscopy analysis has suggested the presence of flaxseed mucilage polymers in the extracted product. Tablets presenting mucilage or HPMC (hydroxypropyl methylcellulose) and tablets without polymer were prepared based on the wet granulation technique. Matrix tablets presenting mucilage or HPMC have shown similar dissolution profiles, as well as similar potential in drug release control.

Conclusion

The product extracted from flaxseed under simple conditions, even without undergoing purification process, can have high technological value in the pharmaceutical industry because it has excellent potential to be used as excipient for matrix tablet manufacturing.

中文翻译：

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通过使用总亚麻籽粘胶作为阻燃聚合物开发和展示基质片剂

目的

评估亚麻总粘液用作药物释放抑制剂的潜力。为此，对种子进行了简单且可扩展的提取过程，该过程包括很少的步骤，没有基于醇的沉淀。基于亲水性聚合物的基质片剂是开发调释系统的最简单形式之一。

方法

将亚麻子以1:13的比例添加到蒸馏水中：将悬浮液在室温下连续搅拌24小时。将亚麻籽过筛，将亚麻籽总粘液冷冻干燥。随后，通过傅立叶变换红外光谱法（IV-TF）在650至4000cm ^-1的波长范围内分析样品。

结果

红外（IR）光谱分析表明提取产物中存在亚麻籽粘胶聚合物。基于湿法制粒技术，制备具有粘液或HPMC（羟丙基甲基纤维素）的片剂和不具有聚合物的片剂。呈现粘液或HPMC的基质片剂显示出相似的溶出曲线，以及在药物释放控制中的相似潜力。

结论

在简单的条件下从亚麻籽中提取的产品，即使不经过纯化工艺，也具有很高的技术价值，因为它具有用作基质片剂生产的赋形剂的潜力。