Purpose

Does IDEF mapping help monitor the technical process of IUI and explore the potential improvements which might contribute to increased pregnancy and live birth rates?

Method

Retrospective analysis of 1729 homologous IUI cycles of couples attending a fertility clinic in a university hospital setting. Standardized conventional semen parameters were analyzed and the semen samples prepared via discontinuous density gradient centrifugation.

Results

There was no significant association between sperm concentration, motility and morphology (analysis phase), and pregnancy outcome. Only female and male ages were significantly associated with the pregnancy outcome. There was a significant difference in the odds on clinical pregnancies and live births when analysis was ≤ 21 min initiated, and < 107 min between sample production and IUI, adjusted for male and female age.

Conclusions

Adjusting for the couple’s age, we could show that time intervals between semen production and analysis and IUI when kept low significantly influenced clinical pregnancies and live births.

中文翻译：

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精液产生、分析开始和 IUI 之间的时间间隔显着影响临床妊娠和活产

目的

IDEF 映射是否有助于监控 IUI 的技术过程并探索可能有助于提高妊娠率和活产率的潜在改进？

方法

对 1729 对在大学医院的生育诊所就诊的夫妇进行的 1729 例同源 IUI 周期的回顾性分析。分析标准化的常规精液参数并通过不连续密度梯度离心制备精液样品。

结果

精子浓度、活力和形态（分析阶段）与妊娠结局之间没有显着关联。只有女性和男性年龄与妊娠结局显着相关。当分析开始 ≤ 21 分钟时，临床妊娠和活产的几率存在显着差异，而样本生产和 IUI 之间的时间 < 107 分钟，针对男性和女性年龄进行了调整。

结论

调整这对夫妇的年龄后，我们可以证明精液生产和分析之间的时间间隔以及 IUI 在保持较低水平时会显着影响临床妊娠和活产。