Appropriate perception and representation of sensory stimuli pose an everyday challenge to the brain. In order to represent the wide and unpredictable array of environmental stimuli, principle neurons of associative learning regions receive sparse, combinatorial sensory inputs. Despite the broad role of such networks in sensory neural circuits, the developmental mechanisms underlying their emergence are not well understood. As mammalian sensory coding regions are numerically complex and lack the accessibility of simpler invertebrate systems, we chose to focus this review on the numerically simpler, yet functionally similar, Drosophila mushroom body calyx. We bring together current knowledge about the cellular and molecular mechanisms orchestrating calyx development, in addition to drawing insights from literature regarding construction of sparse wiring in the mammalian cerebellum. From this, we formulate hypotheses to guide our future understanding of the development of this critical perceptual center.

中文翻译：

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解开电线：蘑菇体花萼中稀疏分布连接的发展

对感官刺激的适当感知和表征对大脑构成了日常挑战。为了表示广泛且不可预测的环境刺激，联想学习区域的主要神经元接收稀疏的组合感觉输入。尽管此类网络在感觉神经回路中具有广泛的作用，但其出现背后的发展机制尚不清楚。由于哺乳动物的感觉编码区域在数值上很复杂，并且缺乏更简单的无脊椎动物系统的可及性，我们选择将这篇综述集中在数值上更简单但功能相似的果蝇蘑菇体花萼上。我们汇集了有关协调花萼发育的细胞和分子机制的当前知识，除了从有关哺乳动物小脑稀疏布线构造的文献中汲取见解。由此，我们提出假设来指导我们未来对这个关键感知中心发展的理解。