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Less mechanical loading attenuates osteoarthritis by reducing cartilage degeneration, subchondral bone remodelling, secondary inflammation, and activation of NLRP3 inflammasome.
Bone & Joint Research ( IF 4.6 ) Pub Date : 2021-1-6 , DOI: 10.1302/2046-3758.910.bjr-2019-0368.r2
Zhennian He 1 , Pengfei Nie 1 , Jianli Lu 2 , Yong Ling 1 , Jian Guo 1 , Bin Zhang 1 , Jianghua Hu 1 , Jiawei Liao 1 , Jie Gu 1 , Bo Dai 1 , Zhiyun Feng 2
Affiliation  

Osteoarthritis (OA) is a disabling joint disorder and mechanical loading is an important pathogenesis. This study aims to investigate the benefits of less mechanical loading created by intermittent tail suspension for knee OA.

中文翻译:

较少的机械负荷可通过减少软骨变性,软骨下骨重塑,继发性炎症和NLRP3炎性体的活化来减轻骨关节炎。

骨关节炎(OA)是一种致残性关节疾病,机械负荷是重要的发病机制。这项研究旨在研究间歇性尾部悬吊对膝OA产生的较小机械负荷的好处。
更新日期:2021-01-07
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