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Susceptibility to the novel coronavirus disease (COVID-19) is associated with ABO and Rh blood groups: a case-control study from Afghanistan
Egyptian Journal of Medical Human Genetics Pub Date : 2021-01-05 , DOI: 10.1186/s43042-020-00124-x Khyber Saify , Mohammad Sarwar Alborz , Mostafa Saadat
Egyptian Journal of Medical Human Genetics Pub Date : 2021-01-05 , DOI: 10.1186/s43042-020-00124-x Khyber Saify , Mohammad Sarwar Alborz , Mostafa Saadat
There are preliminary studies about the association between COVID-19 and ABO phenotypes and the results are controversial. There are only two studies which investigated the association of Rh blood groups in addition to ABO with COVID-19; however, in the statistical analysis ABO and Rh blood groups have been considered separately. Therefore, the present case-control study was performed to determine the association of COVID-19 with ABO blood groups considering the Rh blood groups simultaneously. The study was conducted in Kunduz COVID-19 treatment specific center, Spin-Zar Hospital (Kunduz Province, North East Afghanistan). A total of 301 confirmed COVID-19 cases and 1039 healthy blood donors as control group were included in the study. The Rh− phenotype strongly increased the risk of COVID-19 (OR = 2.97, 95% CI 1.86–3.89, P < 0.001). Although blood group A increased the risk of developing COVID-19, the association did not reach statistical significance. In analysis of the combination phenotypes, the A− blood group remarkably increased the risk of COVID-19 (OR = 7.24, 95% CI 3.62–14.4, P < 0.001). Multivariate analysis revealed that the interaction of Rh and ABO is significant (P < 0.013). These findings indicate that susceptibility to COVID-19 is strongly associated with A− blood group.
中文翻译:
对新型冠状病毒病 (COVID-19) 的易感性与 ABO 和 Rh 血型有关:来自阿富汗的病例对照研究
有关于 COVID-19 与 ABO 表型之间关联的初步研究,结果存在争议。只有两项研究调查了除 ABO 外的 Rh 血型与 COVID-19 的关系;然而,在统计分析中,ABO 和 Rh 血型被分开考虑。因此,本病例对照研究旨在确定 COVID-19 与同时考虑 Rh 血型的 ABO 血型的关联。该研究在昆都士 COVID-19 治疗特定中心 Spin-Zar 医院(阿富汗东北部昆都士省)进行。共有 301 名确诊的 COVID-19 病例和 1039 名健康献血者作为对照组被纳入研究。Rh− 表型大大增加了 COVID-19 的风险(OR = 2.97,95% CI 1.86–3.89,P < 0.001)。尽管血型 A 增加了患 COVID-19 的风险,但这种关联并未达到统计学显着性。在对组合表型的分析中,A- 血型显着增加了 COVID-19 的风险(OR = 7.24,95% CI 3.62–14.4,P < 0.001)。多变量分析显示,Rh 和 ABO 的相互作用显着(P < 0.013)。这些发现表明对 COVID-19 的易感性与 A- 血型密切相关。
更新日期:2021-01-05
中文翻译:
对新型冠状病毒病 (COVID-19) 的易感性与 ABO 和 Rh 血型有关:来自阿富汗的病例对照研究
有关于 COVID-19 与 ABO 表型之间关联的初步研究,结果存在争议。只有两项研究调查了除 ABO 外的 Rh 血型与 COVID-19 的关系;然而,在统计分析中,ABO 和 Rh 血型被分开考虑。因此,本病例对照研究旨在确定 COVID-19 与同时考虑 Rh 血型的 ABO 血型的关联。该研究在昆都士 COVID-19 治疗特定中心 Spin-Zar 医院(阿富汗东北部昆都士省)进行。共有 301 名确诊的 COVID-19 病例和 1039 名健康献血者作为对照组被纳入研究。Rh− 表型大大增加了 COVID-19 的风险(OR = 2.97,95% CI 1.86–3.89,P < 0.001)。尽管血型 A 增加了患 COVID-19 的风险,但这种关联并未达到统计学显着性。在对组合表型的分析中,A- 血型显着增加了 COVID-19 的风险(OR = 7.24,95% CI 3.62–14.4,P < 0.001)。多变量分析显示,Rh 和 ABO 的相互作用显着(P < 0.013)。这些发现表明对 COVID-19 的易感性与 A- 血型密切相关。