A convenient, effective, and low-cost method was developed for the determination of 38 pharmaceuticals and personal care products (PPCPs), including 19 antibiotics in surface water samples by lyophilization combined with liquid chromatography-tandem quadrupole mass spectrometry (LC-MS/MS). The components of the extraction solvent, the volume of the water sample, and the volume of extraction solvent were successively optimized. The analytes in 80 mL water samples were concentrated by lyophilization, eluted effectively by the solvent of 2 mL acetonitrile, 2 mL acetone, and 2 mL ultrapure water. The method detection limits ranged from 0.02 ng L⁻¹ (caffeine) to 0.17 μg L⁻¹ (glibenclamide). The recoveries of 30 analytes ranged from 40.0% (sulfaguanidine) to 124.4% (flumequine). The relative standard deviations of all analytes were below 21% except ciprofloxacin (29%). The performance of the optimized method was comparable to the solid phase extraction and ultrasonic extraction method with much less consumption of labor, organic solvent, and consumables. The developed method was successfully applied to surface river water, reservoir water, and effluent of the wastewater treatment plant.

中文翻译：

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冻干-液相色谱-串联质谱法测定水中的38种药品和个人护理产品

通过冻干-液相色谱-串联四极杆质谱法（LC-MS / MS），开发了一种简便，有效且低成本的方法，用于测定38种药品和个人护理产品（PPCP），包括地表水样品中的19种抗生素）。依次优化了萃取溶剂的成分，水样的体积和萃取溶剂的体积。通过冻干浓缩80 mL水样品中的分析物，用2 mL乙腈，2 mL丙酮和2 mL超纯水的溶剂有效洗脱。方法的检测限范围为0.02 ng L ^-1（咖啡因）至0.17μgL ^-1（格列本脲）。30种分析物的回收率范围为40.0％（磺胺胍）至124.4％（氟尿嘧啶）。除环丙沙星（29％）外，所有分析物的相对标准偏差均低于21％。优化方法的性能可与固相萃取和超声萃取方法相媲美，所需的劳动，有机溶剂和消耗品少得多。所开发的方法已成功应用于地表河水，水库水和废水处理厂的出水。