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Dissociating Representations of Time and Number in Reinforcement-Rate Learning by Deletion of the GluA1 AMPA Receptor Subunit in Mice
Psychological Science ( IF 10.172 ) Pub Date : 2021-01-04 , DOI: 10.1177/0956797620960392
Joseph M Austen 1 , Corran Pickering 1 , Rolf Sprengel 2 , David J Sanderson 1
Affiliation  

Theories of learning differ in whether they assume that learning reflects the strength of an association between memories or symbolic encoding of the statistical properties of events. We provide novel evidence for symbolic encoding of informational variables by demonstrating that sensitivity to time and number in learning is dissociable. Whereas responding in normal mice was dependent on reinforcement rate, responding in mice that lacked the GluA1 AMPA receptor subunit was insensitive to reinforcement rate and, instead, dependent on the number of times a cue had been paired with reinforcement. This suggests that GluA1 is necessary for weighting numeric information by temporal information in order to calculate reinforcement rate. Sample sizes per genotype varied between seven and 23 across six experiments and consisted of both male and female mice. The results provide evidence for explicit encoding of variables by animals rather than implicit encoding via variations in associative strength.

中文翻译:

通过删除小鼠中的 GluA1 AMPA 受体亚基来分离强化率学习中时间和数量的表示

学习理论的不同之处在于它们是否假设学习反映了记忆之间关联的强度或事件统计特性的符号编码。我们通过证明学习中对时间和数量的敏感性是可分离的,为信息变量的符号编码提供了新的证据。正常小鼠的反应取决于强化率,而缺乏 GluA1 AMPA 受体亚基的小鼠的反应对强化率不敏感,而是取决于提示与强化配对的次数。这表明 GluA1 对于通过时间信息对数字信息进行加权以计算强化率是必要的。在六个实验中,每个基因型的样本量在 7 到 23 之间变化,并且由雄性和雌性小鼠组成。
更新日期:2021-01-04
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