Abstract

A new flavanone and a new chalcone, brandisianones F and G, were purified from the roots of Millettia brandisiana Kurz, moreover, sixteen known compounds were found. The chemical structures of all isolated compounds were identified using spectroscopic methods including 1D-NMR, 2D-NMR, MS, IR and CD data. Chalcone 15 exhibited the most cytotoxic activity against liver cancer, HepG2, and cholangiocarcinoma, KKU-M156, cell lines with IC₅₀ values of 1.74 ± 0.91 and 1.95 ± 0.95 µg/mL, respectively. Chalcones 2, 14, 16 and 18 as well as flavones 5, 6 and 12 showed moderate cytotoxicity with IC₅₀ values ranging from 5.39 to 14.00 µg/mL.

摘要

从鸡血藤的根中提纯出一种新的黄烷酮和一种新的查尔酮，即brandisianones F和G，此外，还发现了16种已知化合物。使用光谱方法鉴定所有分离化合物的化学结构，包括 1D-NMR、2D-NMR、MS、IR 和 CD 数据。查尔酮15对肝癌 HepG2 和胆管癌 KKU-M156 细胞系表现出最强的细胞毒活性，IC ₅₀值分别为 1.74 ± 0.91 和 1.95 ± 0.95 µg/mL。查尔酮2 , 14 , 16和18以及黄酮5 , 6和12显示出中等的细胞毒性，IC ₅₀值范围为 5.39 至 14.00 µg/mL。