Adult hippocampal neurogenesis plays an important role in neuronal plasticity and maintenance in mammals. Low-threshold voltage-gated T-type calcium channels produce calcium spikes that increase fast action potentials in newborn cells in the hippocampal dentate gyrus (DG); however, their role in adult hippocampal neurogenesis remains unclear. Here, we demonstrate impaired adult hippocampal neurogenesis in Cav3.1T-type calcium channel knockout mice.

中文翻译：

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Cav3.1 t型钙通道对于成年海马新生细胞的细胞增殖和存活至关重要

成年海马神经发生在哺乳动物的神经元可塑性和维持中起重要作用。低阈值电压门控T型钙通道会产生钙尖峰，从而增加海马齿状回（DG）新生细胞的快速动作电位。然而，它们在成年海马神经发生中的作用仍不清楚。在这里，我们证明了Cav3.1T型钙通道基因敲除小鼠中受损的成人海马神经发生。