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Preventing Colitis-Associated Colon Cancer With Antioxidants: A Systematic Review
Cellular and Molecular Gastroenterology and Hepatology ( IF 7.2 ) Pub Date : 2021-01-05 , DOI: 10.1016/j.jcmgh.2020.12.013
Thergiory Irrazabal 1 , Bhupesh K Thakur 2 , Kenneth Croitoru 3 , Alberto Martin 2
Affiliation  

Inflammatory bowel disease (IBD) patients have an increased risk of developing colitis-associated colon cancer (CAC); however, the basis for inflammation-induced genetic damage requisite for neoplasia is unclear. Several studies have shown that IBD patients have signs of increased oxidative damage, which could be a result of genetic and environmental factors such as an excess in oxidant molecules released during chronic inflammation, mitochondrial dysfunction, a failure in antioxidant capacity, or oxidant promoting diets. It has been suggested that chronic oxidative environment in the intestine leads to the DNA lesions that precipitate colon carcinogenesis in IBD patients. Indeed, several preclinical and clinical studies show that different endogenous and exogenous antioxidant molecules are effective at reducing oxidation in the intestine. However, most clinical studies have focused on the short-term effects of antioxidants in IBD patients but not in CAC. This review article examines the role of oxidative DNA damage as a possible precipitating event in CAC in the context of chronic intestinal inflammation and the potential role of exogenous antioxidants to prevent these cancers.



中文翻译:

用抗氧化剂预防结肠炎相关结肠癌:系统评价

炎症性肠病(IBD)患者患结肠炎相关结肠癌(CAC)的风险增加;然而,炎症引起的肿瘤形成所需的基因损伤的基础尚不清楚。多项研究表明,IBD 患者有氧化损伤增加的迹象,这可能是遗传和环境因素造成的,例如慢性炎症过程中释放的氧化剂分子过多、线粒体功能障碍、抗氧化能力下降或促进氧化的饮食。有人认为,肠道内的慢性氧化环境会导致 DNA 损伤,从而促进 IBD 患者结肠癌的发生。事实上,一些临床前和临床研究表明,不同的内源性和外源性抗氧化剂分子可有效减少肠道内的氧化。然而,大多数临床研究都关注抗氧化剂对 IBD 患者的短期影响,而不是对 CAC 的影响。这篇综述文章探讨了慢性肠道炎症背景下氧化性 DNA 损伤作为 CAC 中可能的诱发事件的作用,以及外源性抗氧化剂预防这些癌症的潜在作用。

更新日期:2021-02-21
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