Paratuberculosis is an incurable infectious disease that affects several species, including goat (Capra hircus). The etiologic agent is Mycobacterium avium subspecies paratuberculosis (MAP) that has tropism for the intestine, causing anorexia, progressive weight loss and death. In goats, the main transmission route is the ingestion of water and food contaminated by infected feces. Affected animals also eliminate the agent through milk, with a potential biological risk to public health. Thus, the aim of this study was to conduct a research of the literature available in electronic media for a systematic review, followed by a meta-analysis of the results found on prevalence and diagnostic tests adopted in the detection of MAP antibodies and DNA in goat milk. The following search parameters were used: “Mycobacterium avium subsp. paratuberculosis” AND (goat OR small ruminant) AND (milk OR pasteurized milk). Strictly obeying pre-established criteria, 437 articles were selected from the respective electronic databases of scientific content: ScienceDirect (285), PubMed (68), Web of Science (60) and Scopus (24), of which nine papers were elected to the construction of the systematic review and meta-analysis. The prevalence of MAP antibodies in milk detected by milk-ELISA ranged from 1.1 to 67.7% and the prevalence of MAP DNA in goat milk detected by MAP-specific polymerase chain reaction (PCR) ranged from 1.94 to 37.74%. A meta-analysis indicated a combined MAP infection prevalence of 8.24%, but with high heterogeneity among study findings (I² = 98.7%). The identification of the MAP in goat milk implies the need for surveillance of the agent in order to prevent economic losses and impact on public health.

副结核病是一种无法治愈的传染病，会影响几种物种，包括山羊（Capra hircus）。病原是禽分枝杆菌亚种副结核病（MAP）对肠道具有嗜性，导致厌食，体重减轻和死亡。在山羊中，主要的传播途径是摄入被感染的粪便污染的水和食物。患病动物还通过牛奶消除了这种物质，对公众健康具有潜在的生物风险。因此，本研究的目的是对电子媒体上的文献进行研究，以进行系统的综述，然后对用于检测山羊MAP抗体和DNA的流行性和诊断性检测结果进行荟萃分析。牛奶。使用了以下搜索参数：“鸟分枝杆菌亚种。肺结核”AND（山羊或小反刍动物）AND（牛奶或巴氏杀菌牛奶）。严格遵循既定标准，从相应的科学数据库电子数据库中选出437篇文章：ScienceDirect（285），PubMed（68），Web of Science（60）和Scopus（24），其中9篇论文入选该论文。系统评价和荟萃分析的构建。牛奶ELISA法检测到的牛奶中MAP抗体的检出率为1.1至67.7％，而MAP特异性聚合酶链反应（PCR）检测的山羊奶中的MAP DNA检出率为1.94至37.74％。荟萃分析表明，合并的MAP感染率为8.24％，但研究结果之间的异质性较高（I ² = 98.7％）。山羊奶中MAP的鉴定意味着需要对制剂进行监控，以防止经济损失和对公共健康的影响。