当前位置: X-MOL 学术Cancer Cell › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Acute Immune Signatures and Their Legacies in Severe Acute Respiratory Syndrome Coronavirus-2 Infected Cancer Patients
Cancer Cell ( IF 50.3 ) Pub Date : 2021-01-05 , DOI: 10.1016/j.ccell.2021.01.001
Sultan Abdul-Jawad 1 , Luca Baù 2 , Thanussuyah Alaguthurai 3 , Irene Del Molino Del Barrio 4 , Adam G Laing 5 , Thomas S Hayday 5 , Leticia Monin 6 , Miguel Muñoz-Ruiz 6 , Louisa McDonald 7 , Isaac Francos Quijorna 8 , Duncan McKenzie 6 , Richard Davis 5 , Anna Lorenc 5 , Julie Nuo En Chan 1 , Sarah Ryan 9 , Eva Bugallo-Blanco 1 , Rozalyn Yorke 9 , Shraddha Kamdar 5 , Matthew Fish 10 , Iva Zlatareva 5 , Pierre Vantourout 5 , Aislinn Jennings 10 , Sarah Gee 5 , Katie Doores 11 , Katharine Bailey 12 , Sophie Hazell 12 , Julien De Naurois 13 , Charlotte Moss 14 , Beth Russell 14 , Aadil A Khan 15 , Mark Rowley 16 , Reuben Benjamin 17 , Deborah Enting 14 , Doraid Alrifai 13 , Yin Wu 18 , You Zhou 19 , Paul Barber 1 , Tony Ng 1 , James Spicer 1 , Mieke Van Hemelrijck 14 , Mayur Kumar 20 , Jennifer Vidler 21 , Yadanar Lwin 21 , Paul Fields 22 , Sophia N Karagiannis 23 , Anthony C C Coolen 24 , Anne Rigg 13 , Sophie Papa 25 , Adrian C Hayday 26 , Piers E M Patten 27 , Sheeba Irshad 28
Affiliation  

Given the immune system's importance for cancer surveillance and treatment, we have investigated how it may be affected by SARS-CoV-2 infection of cancer patients. Across some heterogeneity in tumor type, stage, and treatment, virus-exposed solid cancer patients display a dominant impact of SARS-CoV-2, apparent from the resemblance of their immune signatures to those for COVID-19+ non-cancer patients. This is not the case for hematological malignancies, with virus-exposed patients collectively displaying heterogeneous humoral responses, an exhausted T cell phenotype and a high prevalence of prolonged virus shedding. Furthermore, while recovered solid cancer patients' immunophenotypes resemble those of non-virus-exposed cancer patients, recovered hematological cancer patients display distinct, lingering immunological legacies. Thus, while solid cancer patients, including those with advanced disease, seem no more at risk of SARS-CoV-2-associated immune dysregulation than the general population, hematological cancer patients show complex immunological consequences of SARS-CoV-2 exposure that might usefully inform their care.



中文翻译:

严重急性呼吸综合征冠状病毒 2 感染癌症患者的急性免疫特征及其遗留问题

鉴于免疫系统对于癌症监测和治疗的重要性,我们研究了癌症患者的 SARS-CoV-2 感染对免疫系统的影响。尽管肿瘤类型、分期和治疗存在一定的异质性,但暴露于病毒的实体瘤患者表现出 SARS-CoV-2 的显着影响,这一点从他们的免疫特征与 COVID-19 + 非癌症患者的相似性中可以明显看出。血液恶性肿瘤的情况并非如此,暴露于病毒的患者集体表现出异质的体液反应、耗尽的 T 细胞表型以及长时间病毒脱落的高发生率。此外,虽然康复的实体癌症患者的免疫表型与未暴露于病毒的癌症患者相似,但康复的血液癌症患者表现出独特的、挥之不去的免疫学遗产。因此,虽然实体癌症患者,包括晚期疾病患者,似乎并不比普通人群面临更多 SARS-CoV-2 相关免疫失调的风险,但血液癌症患者表现出暴露于 SARS-CoV-2 的复杂免疫学后果,这可能会有所帮助。告知他们的护理。

更新日期:2021-02-08
down
wechat
bug