4-hydroxynonenal (HNE, 4-hydroxy-2-nonenal) is a primary α,β-unsaturated aldehyde product of lipid peroxidation. The accumulation of HNE increases with aging and the mechanisms are mainly attributable to increased oxidative stress and decreased capacity of HNE elimination. In this review article, we summarize the studies on age-related change of HNE concentration and alteration of HNE metabolizing enzymes (GCL, GST, ALDHs, aldose reductase, and 20S-proteasome), and discuss potential mechanism of age-related decrease in HNE-elimination capacity by focusing on Nrf2 redox signaling.

中文翻译：

---

HNE消除酶的年龄相关变化

4-羟基壬烯醛（HNE，4-羟基-2-壬烯醛）是脂质过氧化作用的主要α，β-不饱和醛产物。HNE的积累随着老化而增加，其机理主要归因于氧化应激的增加和HNE消除能力的降低。在这篇综述文章中，我们总结了与年龄相关的HNE浓度变化和HNE代谢酶（GCL，GST，ALDHs，醛糖还原酶和20S-蛋白酶体）变化的研究，并探讨了与年龄相关的HNE下降的潜在机制通过专注于Nrf2氧化还原信号消除能力。