A micro-machined tip-separable microneedle structure fabricated using a molding process was placed on the end of a metal rod with the outer diameter of 2.0 mm to produce a spear-shaped microneedle, and an applicator for inserting this microneedle into the skin based on a commercially available stamp mechanism was developed. The fabricated spear-shaped microneedle with the needle holder was inserted into the stamp mechanism and a load cell was embedded between the push button and the microneedle for quantitatively evaluating the applied force during microneedle insertion. A PDMS sheet with the Young’s modulus of 0.8 MPa, similar to that of human skin, was used as the artificial skin sample. The tip part was separated from the base and successfully embedded into the skin when the relatively large force of 64.9 N was applied within the time period of 426 ms. The tip was completely embedded to the depth of 0.305 mm below the skin surface, and thus the puncture marks generated by the insertion were almost completely closed thanks to the elasticity of the PDMS at the surface.

将通过模制工艺制造的微加工可分离的针头微针结构放置在外径为2.0 mm的金属棒的末端，以生产矛状微针，并根据该针头将微针插入皮肤开发了可商购的印章机构。将制造的带有持针器的矛状微针插入到压模机构中，并将测力传感器嵌入按钮和微针之间，以定量评估在微针插入过程中施加的力。将杨氏模量为0.8MPa的PDMS片材与人的皮肤相似，用作人造皮肤样品。当相对较大的力为64时，尖端部分与基部分离并成功嵌入皮肤中。在426毫秒的时间段内施加了9N。尖端完全嵌入皮肤表面以下0.305毫米的深度，由于PDMS在表面的弹性，因此插入产生的穿刺痕迹几乎完全闭合。