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The synthesis of hydroxyapatite from artificially grown Red Sea hydrozoan coral for antimicrobacterial drug delivery system applications
Journal of the Australian Ceramic Society ( IF 1.9 ) Pub Date : 2021-01-05 , DOI: 10.1007/s41779-020-00554-1
Ipek Karacan , Nathan Cox , Annette Dowd , Razi Vago , Bruce Milthorpe , Sophie Cazalbou , Besim Ben-Nissan

The hydrozoan Millepora dichotoma (MD) is a typical Red Sea species containing a porous skeleton in the form of aragonite crystalline calcium carbonate. Due to environmental considerations, the artificial production of coralline species under controlled conditions is pertinent and underway. Artificially grown MD was used as a raw material for the production of calcium phosphate, mainly hydroxyapatite bioceramics, to be used in the drug delivery systems as a drug carrier or in the tissue engineering such as bone graft. DTA-TGA, XRD, FT-IR, Raman, and SEM analysis were carried out to analyze both unconverted and converted artificial corals. Hydrothermally converted coral fine powders were loaded with gentamicin (Gm) antibiotic, and the drug-loaded particles were analyzed by SEM. Unconverted coral was mainly aragonite, while hydrothermally treated coral was completely converted to hydroxyapatite. Hydrothermally treated coral was showing agglomerated nodules up to 1-μm size consisting of nanocrystalline hydroxyapatite platelets in the size range of less than 100 nm. The general macropore size of the coral was found to be appropriate for osteoid growth, which is 100 to 600 μm range. These artificially grown corals can be easily produced and used for bone growth and repair and other biomedical applications.



中文翻译:

由人工生长的红海水生珊瑚合成羟基磷灰石用于抗菌药物递送系统

水生(MD)是典型的红海物种,其中含有文石晶体碳酸钙形式的多孔骨架。出于环境方面的考虑,在受控条件下人工生产珊瑚物种的工作正在进行中。人工生长的MD用作生产磷酸钙(主要是羟基磷灰石生物陶瓷)的原料,可在药物输送系统中用作药物载体或在组织工程(如骨移植)中使用。进行了DTA-TGA,XRD,FT-IR,拉曼和SEM分析,以分析未转化和转化的人造珊瑚。在热液转化的珊瑚细粉中加入庆大霉素(Gm)抗生素,然后用SEM分析载药颗粒。未转化的珊瑚主要是文石,而经水热处理的珊瑚已完全转化为羟磷灰石。经水热处理的珊瑚显示结块状结节,大小不超过1μm,由小于100 nm的纳米晶羟基磷灰石血小板组成。发现珊瑚的一般大孔尺寸适合类骨质生长,其范围为100至600μm。这些人造珊瑚很容易生产,可用于骨骼生长和修复以及其他生物医学应用。

更新日期:2021-01-05
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