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Study of the Extremely-Tolerant Brevibacterium linens AE038-8 with Antiviral Activity Against Herpes Simplex Virus Type 1
Current Microbiology ( IF 2.6 ) Pub Date : 2021-01-05 , DOI: 10.1007/s00284-020-02316-5
Daniela Maizel , Franco Maximiliano Salinas , Inés Solórzano , Laura Raiger Iustman , Marcela Alejandra Ferrero , Pablo Jacobo David Mauas , Laura Edith Alché

Brevibacterium linens AE038-8 is an arsenic hyper-tolerant bacterial strain, previously isolated from well water in Tucumán, Argentina. The aim of this study was to characterize this strain regarding its resistance to different stress factors and to evaluate its antiviral activity against Herpes simplex virus type 1 (HSV-1). We found that B. linens AE038-8 was capable of tolerating high concentrations of heavy metals such as Cd(II), Cr(VI) and Cu(II). When grown in the presence of NaCl, it could tolerate up to 3 M in LB25 medium. When cultivated, B. linens released to the supernatants a bioactive principle with antiviral activity against HSV-1 virus regardless growth conditions.

中文翻译:

对 1 型单纯疱疹病毒具有抗病毒活性的极端耐受亚麻短杆菌 AE038-8 的研究

亚麻短杆菌 AE038-8 是一种砷超耐受菌株,以前从阿根廷图库曼的井水中分离出来。本研究的目的是表征该菌株对不同应激因素的抵抗力,并评估其对 1 型单纯疱疹病毒 (HSV-1) 的抗病毒活性。我们发现亚麻布 AE038-8 能够耐受高浓度的重金属,如 Cd(II)、Cr(VI) 和 Cu(II)。当在 NaCl 存在下生长时,它可以在 LB25 培养基中耐受高达 3 M。培养时,亚麻布会将一种生物活性成分释放到上清液中,无论生长条件如何,它都具有针对 HSV-1 病毒的抗病毒活性。
更新日期:2021-01-05
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