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NAPROXEN/LAYERED DOUBLE HYDROXIDE COMPOSITES FOR TISSUE-ENGINEERING APPLICATIONS: PHYSICOCHEMICAL CHARACTERIZATION AND BIOLOGICAL EVALUATION
Clays and Clay Minerals ( IF 2.2 ) Pub Date : 2020-12-01 , DOI: 10.1007/s42860-020-00101-w
Marcela P. Bernardo , Bruna C.S. Rodrigues , Tamires D. de Oliveira , Adriana P.M. Guedes , Alzir A. Batista , Luiz H.C. Mattoso

Injured bone tissues can be healed with bone grafts, but this procedure may cause intense pain to the patient. A slow and localized delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) could help to reduce the pain without affecting bone regeneration. The objective of the present study was to use [Mg-Al]-layered double hydroxide (LDH) as a matrix for controlled release of sodium naproxen (NAP). This system could be applied in biomaterial formulations (such as bone grafts) to achieve a local delivery of naproxen. [Mg-Al]-LDH successfully incorporated up to 80% (w/w) of naproxen by the structural reconstruction route, with the [Mg-Al]-LDH interlayer space increasing by 0.55 nm, corresponding to the drug molecule size. The evaluation of the naproxen release kinetics showed that 40% of the drug was delivered over 48 h in aqueous medium (pH 7.4 ± 0.1), indicating the potential of [Mg-Al]-LDH/NAP for local release of naproxen at adequate concentrations. Kinetic modeling showed that the naproxen release process was closely related to the Higuchi model, which considers the drug release as a diffusional process based on Fick’s law. The chemical stability of NAP after the release tests was verified by 1 H NMR. The [Mg-Al]-LDH/NAP also exhibited low cytotoxicity toward fibroblast cells (L929 cell line), without modifications in their morphology and adhesion capacity. These results describe a suitable approach for preparing efficient systems for local delivery of nonsteroidal anti-inflammatory drugs for biomedical applications.

中文翻译:

用于组织工程应用的萘普生/层状双氢氧化物复合材料:物理化学表征和生物评价

受伤的骨组织可以用骨移植物治愈,但这个过程可能会给患者带来剧烈的疼痛。非甾体类抗炎药 (NSAID) 的缓慢局部给药有助于减轻疼痛而不影响骨骼再生。本研究的目的是使用 [Mg-Al] 层状双氢氧化物 (LDH) 作为控制释放萘普生钠 (NAP) 的基质。该系统可应用于生物材料制剂(如骨移植物)以实现萘普生的局部递送。[Mg-Al]-LDH 通过结构重建途径成功掺入了高达 80% (w/w) 的萘普生,[Mg-Al]-LDH 层间距增加了 0.55 nm,对应于药物分子大小。萘普生释放动力学的评估表明,40% 的药物在水性介质 (pH 7. 4 ± 0.1),表明 [Mg-Al]-LDH/NAP 在足够浓度下局部释放萘普生的潜力。动力学模型表明萘普生的释放过程与 Higuchi 模型密切相关,Higuchi 模型将药物释放视为基于 Fick 定律的扩散过程。释放测试后NAP的化学稳定性通过1 H NMR验证。[Mg-Al]-LDH/NAP 还表现出对成纤维细胞(L929 细胞系)的低细胞毒性,其形态和粘附能力没有改变。这些结果描述了一种合适的方法,用于制备用于生物医学应用的非甾体抗炎药局部递送的有效系统。动力学模型表明萘普生的释放过程与 Higuchi 模型密切相关,Higuchi 模型将药物释放视为基于 Fick 定律的扩散过程。释放测试后NAP的化学稳定性通过1 H NMR验证。[Mg-Al]-LDH/NAP 还表现出对成纤维细胞(L929 细胞系)的低细胞毒性,其形态和粘附能力没有改变。这些结果描述了一种合适的方法,用于制备用于生物医学应用的非甾体抗炎药局部递送的有效系统。动力学模型表明萘普生的释放过程与 Higuchi 模型密切相关,Higuchi 模型将药物释放视为基于 Fick 定律的扩散过程。释放测试后NAP的化学稳定性通过1 H NMR验证。[Mg-Al]-LDH/NAP 还表现出对成纤维细胞(L929 细胞系)的低细胞毒性,其形态和粘附能力没有改变。这些结果描述了一种合适的方法,用于制备用于生物医学应用的非甾体抗炎药局部递送的有效系统。[Mg-Al]-LDH/NAP 还表现出对成纤维细胞(L929 细胞系)的低细胞毒性,其形态和粘附能力没有改变。这些结果描述了一种合适的方法,用于制备用于生物医学应用的非甾体抗炎药局部递送的有效系统。[Mg-Al]-LDH/NAP 还表现出对成纤维细胞(L929 细胞系)的低细胞毒性,其形态和粘附能力没有改变。这些结果描述了一种合适的方法,用于制备用于生物医学应用的非甾体抗炎药局部递送的有效系统。
更新日期:2020-12-01
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