Streptococcus agalactiae is a recognized pathogen associated with infections in neonates, elderly, and immunocompromised adults, particularly those with cancer. In the present investigation, clinical-epidemiological features, multidrug resistance profiles, and virulence genes of S. agalactiae strains isolated from cancer patients were investigated. S. agalactiae capsular distribution assays demonstrated that Ia (43.6%) and V (23.6%) types were predominantly detected among 55 clinical isolates tested; only one strain (GBS1428) was capsular type III/ST-17. The fbsB and hylB genes were detected in all isolates, while the iag , lmb , and fbsA genes were detected in 94.5%, 91%, and 91% of oncological isolates, respectively. The combination of PI-1 and PI-2a was the most common (60%) among S. agalactiae strains isolated from oncologic patients. S. agalactiae strains were resistant to tetracycline (85.5%), erythromycin (9%), and clindamycin (5.5%). Norfloxacin non-susceptible was detected in 7.3% of S. agalactiae strains. Our findings reinforce the need for S. agalactiae control measures in Brazil, including cancer patients.

中文翻译：

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从巴西里约热内卢的癌症患者中分离出的无乳链球菌菌株

无乳链球菌是一种公认​​的病原体，与新生儿、老年人和免疫功能低下的成年人，尤其是癌症患者的感染有关。在本研究中，研究了从癌症患者中分离的无乳链球菌菌株的临床流行病学特征、多药耐药性和毒力基因。无乳链球菌荚膜分布分析表明，在 55 个测试的临床分离株中主要检测到 Ia (43.6%) 和 V (23.6%) 型；只有一种菌株 (GBS1428) 是荚膜 III/ST-17 型。在所有分离株中均检测到 fbsB 和 hylB 基因，而在 94.5%、91% 和 91% 的肿瘤分离株中分别检测到 iag 、 lmb 和 fbsA 基因。在从肿瘤患者分离的无乳链球菌菌株中，PI-1 和 PI-2a 的组合最为常见（60%）。S。无乳菌株对四环素 (85.5%)、红霉素 (9%) 和克林霉素 (5.5%) 具有抗性。在 7.3% 的无乳链球菌菌株中检​​测到诺氟沙星不敏感。我们的研究结果加强了巴西对包括癌症患者在内的无乳链球菌控制措施的需求。