According to previous studies of obesity, we found that the association between homocysteine concentrations and obesity was reported controversially. Thus, we carried out this meta-analysis to investigate this association. We searched PubMed, The Cochrane library, and EMBASE database for studies that evaluate the relationship between homocysteine concentrations and obesity from inception to March, 2019. The quality of all included studies was assessed by the Newcastle Ottawa Scale (NOS) and the Agency for Healthcare Research Quality (AHRQ). The RevMan5.3 software and Stata12.0 software were used for conducting all data analyses. Standardized mean differences (SMD) with the corresponding 95% confidence intervals (95% CIs) were used as a measure of effect size to assess the relationship between homocysteine concentrations and obesity through a meta-analysis. The level of significance was set at P < .05. A total of 14 studies were ultimately included in our meta-analysis. Meta-analysis of the 14 studies found remarkable lower homocysteine concentrations in controls than in obese patients (SMD = 0.76, 95% CI = 0.25-1.27, P < .01; I² = 94% and P < .01 for heterogeneity), regardless of nutritional status, dietary habit, insulin resistance (IR) status, special disease history, history of medicine taken, genetic background, and so on. Homocysteine concentrations in nonobese patients with polycystic ovarian syndrome (PCOS) were lower than obese patients with PCOS (SMD = 0.48, 95% CI = 0.20-0.77, P < .01; I² = 39% and P = .18 for heterogeneity). The result of our meta-analysis showed that homocysteine concentrations were significantly elevated among obese patients.

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同型半胱氨酸与肥胖之间的关联：荟萃分析

根据先前对肥胖的研究，我们发现同型半胱氨酸浓度与肥胖之间的关联存在争议。因此，我们进行了这项荟萃分析来调查这种关联。我们在 PubMed、Cochrane 图书馆和 EMBASE 数据库中搜索了从开始到 2019 年 3 月评估同型半胱氨酸浓度与肥胖之间关系的研究。所有纳入研究的质量均由纽卡斯尔渥太华量表 (NOS) 和医疗保健机构评估研究质量 (AHRQ)。RevMan5.3软件和Stata12.0软件用于进行所有数据分析。使用具有相应 95% 置信区间 (95% CI) 的标准化平均差异 (SMD) 作为效应大小的衡量标准，以通过荟萃分析评估同型半胱氨酸浓度与肥胖之间的关系。显着性水平设置为P  < .05。共有 14 项研究最终被纳入我们的荟萃分析。对 14 项研究的荟萃分析发现，对照组的同型半胱氨酸浓度明显低于肥胖患者（SMD = 0.76，95% CI = 0.25-1.27，P  < .01；I ²  = 94%，异质性P  < .01），无论营养状况、饮食习惯、胰岛素抵抗 (IR) 状况、特殊疾病史、用药史、遗传背景等。非肥胖多囊卵巢综合征 (PCOS) 患者的同型半胱氨酸浓度低于肥胖的 PCOS 患者（SMD = 0.48，95% CI = 0.20-0.77，P  < .01；I ²  = 39% 和P = .18 异质性）。我们的荟萃分析结果表明，肥胖患者的同型半胱氨酸浓度显着升高。