This study utilizes the Science of Behavior Change (SOBC) experimental medicine approach to evaluate the effects of a 3-month, individually prescribed progressive exercise training program on neurobiological, cognitive and motivational mechanisms by which our exercise-training paradigm may foster exercise maintenance. We will investigate hypothesized relationships between exercise-training associated augmentation of neuropeptide Y (NPY) system function and improvements in self-regulation and reward sensitivity-cognitive control and motivational processes posited to promote self-efficacy and intrinsic motivation, which have been shown to predict exercise maintenance. This study will recruit Veterans with chronic low back pain and posttraumatic stress disorder (PTSD). Procedures include a baseline, acute cardiopulmonary exercise challenge assessment that will inform the exercise prescription for a 12-week progressive exercise training program comprised of three 45-minute aerobic exercise sessions per week-all of which will be supervised by an exercise physiologist. Additionally, a week-7 and week-14 exercise challenge assessment will track changes in NPY system function and the variables of interest. We hypothesize that increases in the capacity to release NPY in response to acute exercise testing will be associated with improvements in self-regulation and reward sensitivity, which will in turn be associated with self-efficacy and intrinsic motivation to maintain regular exercise. Ninety participants will be randomized either to the "active exercise training condition" or to the "wait list symptom monitoring condition". The study aims to demonstrate the feasibility of procedures and elucidate mechanisms relevant to developing individually prescribed, motivationally based exercise regimens to reduce negative consequences of PTSD and low back pain over the long-term. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

中文翻译：

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在疼痛和创伤后应激障碍中维持运动的适度调解：一项随机试验。

这项研究利用行为改变科学（SOBC）实验医学方法评估了为期3个月的个体处方渐进式运动训练计划对神经生物学，认知和动机机制的影响，通过这些训练手段，我们的运动训练范例可以促进运动维持。我们将研究与运动训练相关的神经肽Y（NPY）系统功能增强与自我调节和奖励敏感度-认知控制以及旨在促进自我效能和内在动机的动机过程之间的关系的假设关系。运动维护。这项研究将招募患有慢性下腰痛和创伤后应激障碍（PTSD）的退伍军人。程序包括基线，急性心肺运动挑战评估，将为一项为期12周的进行性运动训练计划提供运动处方，该计划包括每周进行三个45分钟的有氧运动训练，所有这些将由运动生理学家监督。此外，第7周和第14周的运动挑战评估将跟踪NPY系统功能的变化和感兴趣的变量。我们假设响应急性运动测试而释放NPY的能力增加将与自我调节和奖赏敏感性的提高相关，而反过来又与自我效能和保持规律运动的内在动力有关。九十名参与者将被随机分为“主动运动训练条件”或“等待名单症状监测条件”。这项研究旨在证明与制定单独制定的基于动机的运动方案相关的程序和机制的可行性，以长期减少PTSD的不良后果和腰痛。（PsycInfo数据库记录（c）2020 APA，保留所有权利）。