Little is known about how anger-associated brain regions integrate and modulate external input. Therefore, we investigated the neural connectivity architecture of anger processing using a dynamic causal modeling (DCM) approach. Thirteen subjects underwent functional magnetic resonance imaging (fMRI) while viewing anger-inducing film clips. Conventional fMRI and DCM analyses were conducted to identify a dominant connectivity model. Viewing anger-inducing film clips led to activation in the left superior temporal gyrus, left insula, and left orbitofrontal cortex (OFC). The results of a group-level comparison of eight connectivity models based on conventional fMRI findings showed superiority of the model including reciprocal effective connectivities between the left insula, left superior temporal gyrus, and left orbitofrontal gyrus and bottom-up connectivity from the left superior temporal gyrus to the left orbitofrontal gyrus. Positive coupling effects were identified for connectivities between the left superior temporal gyrus and left insula and the left superior temporal gyrus and left OFC. A negative coupling effect was identified for connectivity between the left OFC and left insula. In conclusion, we propose a model of effective connectivity associated with the anger experience based on dynamic causal modeling. The findings have implications for various psychiatric disorders related to abnormalities in anger processing.

中文翻译：

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健康年轻男性愤怒体验期间有效连通性的动态因果建模：7T 磁共振成像研究

人们对与愤怒相关的大脑区域如何整合和调节外部输入知之甚少。因此，我们使用动态因果建模 (DCM) 方法研究了愤怒处理的神经连接架构。13 名受试者在观看诱发愤怒的影片剪辑时接受了功能性磁共振成像 (fMRI)。进行传统的 fMRI 和 DCM 分析以确定主要的连接模型。观看诱发愤怒的影片剪辑导致左侧颞上回、左侧脑岛和左侧眶额皮质 (OFC) 的激活。基于传统 fMRI 发现的八种连接模型的组级比较结果显示该模型的优越性，包括左脑岛、左颞上回、和左眶额回以及从左颞上回到左眶额回的自下而上的连接。对于左侧颞上回和左侧岛叶以及左侧颞上回和左侧 OFC 之间的连接，确定了正耦合效应。左侧 OFC 和左侧脑岛之间的连接被确定为负耦合效应。总之，我们提出了一个基于动态因果模型的与愤怒体验相关的有效连接模型。这些发现对与愤怒处理异常相关的各种精神疾病有影响。对于左侧颞上回和左侧岛叶以及左侧颞上回和左侧 OFC 之间的连接，确定了正耦合效应。左侧 OFC 和左侧脑岛之间的连接被确定为负耦合效应。总之，我们提出了一个基于动态因果模型的与愤怒体验相关的有效连接模型。这些发现对与愤怒处理异常相关的各种精神疾病有影响。对于左侧颞上回和左侧岛叶以及左侧颞上回和左侧 OFC 之间的连接，确定了正耦合效应。左侧 OFC 和左侧脑岛之间的连接被确定为负耦合效应。总之，我们提出了一个基于动态因果模型的与愤怒体验相关的有效连接模型。这些发现对与愤怒处理异常相关的各种精神疾病有影响。