Objective: Pancreatic cancer (PC) is a serious disease with poor outcomes, and its prevalence has been increasing steadily. The circadian rhythm (CR) is involved in multiple physiological events and maintains homeostasis. Alterations in the CR elevate the risk of developing cancer. The present case–control research was carried out to estimate the possible association between PERIOD2/PERIOD3 (PER2/PER3) gene variable number tandem repeat polymorphism (VNTR) variants and PC in the Turkish population.

中文翻译：

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PER2 / PER3可变数目串联重复多态性变异与胰腺癌易感性和临床特征的可能关联

目的：胰腺癌（PC）是一种严重的疾病，预后较差，其患病率一直在稳定增长。昼夜节律（CR）参与多种生理事件，并保持体内平衡。CR的改变会增加患癌的风险。本病例对照研究进行了估计土耳其人口中PERIOD2 / PERIOD3（ PER2 / PER3）基因可变数目串联重复多态性（VNTR）变异与PC之间的可能关联。