Purpose To quantify retinal and choriocapillaris (CC) microvasculature in highly myopic (HM) eyes with myopic macular degeneration (MMD) using swept-source optical coherence tomography angiography (SS-OCTA). Methods 162 HM eyes (spherical equivalent ≤ −6.0 dioptres or axial length (AL) ≥26.5 mm) from 98 participants were enrolled, including 60 eyes (37.0%) with tessellated fundus, 54 eyes (33.3%) with peripapillary diffuse chorioretinal atrophy (PDCA), 27 eyes (16.7%) with macular diffuse chorioretinal atrophy (MDCA) and 21 eyes (13.0%) with patchy or macular atrophy. PLEX Elite 9000 SS-OCTA was performed to obtain perfusion densities (PD) of the superficial and deep retinal capillary plexus, and CC signal voids (number, area and density). Results Retinal PD decreased with increasing severity of MMD. Multivariable analysis showed that after adjustment of age and other factors, retinal PD decreased significantly in eyes with longer AL (β≤−0.51, p<0.001) and with an MMD severity of MDCA or worse (β≤−1.63, p<0.001). Reduced retinal PD were significantly associated with worse vision (β≤−0.01, p≤0.04). In terms of CC signal voids, multivariable analysis showed that longer AL (p<0.001), but not MMD severity (p≥0.12) was significantly associated with CC signal void changes in the earliest stage of MMD. Conclusion We demonstrate significant OCTA alterations in the retina and CC in HM eyes with varying severities of MMD. In eyes with early-stage PDCA, lower retinal PD and more extensive CC signal voids are predominantly associated with increasing AL. In contrast, in eyes with MDCA or worse, MMD itself was associated with sparser retinal and CC circulation. Data are available on reasonable request. High-resolution digital photographs and OCTA imagings were stored on the Singapore Eye Research Institute server. The corresponding author has full access to all the data in the study.

中文翻译：

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高度近视眼黄斑变性视网膜微血管和脉络膜毛细血管的定量 OCT 血管造影

目的 使用扫描源光学相干断层扫描血管造影 (SS-OCTA) 量化高度近视 (HM) 患有近视黄斑变性 (MMD) 的视网膜和脉络膜毛细血管 (CC) 微血管系统。方法 入组 98 名参与者的 162 只 HM 眼（等效球面屈光度≤-6.0 屈光度或眼轴长度（AL）≥26.5 mm），其中 60 眼（37.0%）眼底镶嵌，54 眼（33.3%）眼底弥漫性脉络膜视网膜萎缩（ PDCA)、27 只眼 (16.7%) 患有黄斑弥漫性脉络膜视网膜萎缩 (MDCA) 和 21 只眼 (13.0%) 患有斑片状或黄斑萎缩。执行 PLEX Elite 9000 SS-OCTA 以获得浅层和深层视网膜毛细血管丛的灌注密度 (PD)，以及 CC 信号空隙（数量、面积和密度）。结果视网膜PD随着MMD严重程度的增加而降低。多变量分析显示，在调整年龄和其他因素后，AL 较长（β≤-0.51，p<0.001）和 MMD 严重程度为 MDCA 或更差（β≤-1.63，p<0.001）的眼睛视网膜 PD 显着下降。 . 减少的视网膜 PD 与视力较差显着相关（β≤-0.01，p≤0.04）。在 CC 信号空洞方面，多变量分析表明，较长的 AL (p<0.001)，而不是 MMD 严重程度 (p≥0.12) 与 MMD 早期的 CC 信号空洞变化显着相关。结论 我们证明了具有不同严重程度的 MMD 的 HM 眼中视网膜和 CC 的显着 OCTA 改变。在早期 PDCA 的眼睛中，较低的视网膜 PD 和更广泛的 CC 信号空洞主要与 AL 增加有关。相反，在患有 MDCA 或更严重的眼睛中，MMD 本身与稀疏的视网膜和 CC 循环有关。可根据合理要求提供数据。高分辨率数码照片和 OCTA 图像存储在新加坡眼科研究所服务器上。通讯作者可以完全访问研究中的所有数据。