Introduction: Theta-burst stimulation (TBS) is a safe non-invasive neurostimulation technique used to improve cognitive and neuropsychiatric impairments. Combined outcome evaluation using event-related potentials (ERPs) and neuropsychological tests may allow a more thorough assessment of TBS treatment efficacy; however, some mixed results have been found, and their use remains scarce. Our main objective was to evaluate whether a session of TBS to the left dorsolateral prefrontal cortex (DLPFC) can impact upon the performance of both neuropsychological and neurophysiological tests. Methods: This double-blind sham-controlled study involved 28 healthy adults, between 18 and 30 years. Volunteers were randomly allocated to receive excitatory (intermittent [iTBS]), inhibitory (continuous TBS [cTBS]) or sham stimulation on the left DLPFC. Subjects were evaluated using ERPs (auditory oddball paradigm P300) and neuropsychological tests (Trail making test [TMT] and Stroop test of words and colours [STWC]), using a pre-post stimulation protocol. Results: Inhibitory stimulation led to significantly delayed P300 peak latencies (p #x3c; 0.001), with no consistent change in N2P3 amplitudes. cTBS also significantly influenced the expected group performance in Stroop C and Stroop interference (p = 0.025) compared to the iTBS and sham groups. No significant results were found in TMT tests after TBS. Conclusion: Our results suggest that P300 and specific Stroop colour and words test parameters can be similarly influenced by the same TBS protocol. This emphasizes the importance of mixed evaluation using neuropsychological and neurophysiological resources in research associated with the use of transcranial magnetic stimulation and cognition.
Neuropsychobiology

中文翻译：

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Theta-Burst 刺激能够影响认知处理：一项 P300 和神经心理学测试研究

简介： Theta-burst 刺激 (TBS) 是一种安全的非侵入性神经刺激技术，用于改善认知和神经精神障碍。使用事件相关电位 (ERPs) 和神经心理学测试的联合结果评估可以更彻底地评估 TBS 治疗效果；然而，已经发现了一些混合的结果，并且它们的使用仍然很少。我们的主要目标是评估左背外侧前额叶皮层 (DLPFC) 的 TBS 会话是否会影响神经心理学和神经生理学测试的表现。方法：这项双盲假对照研究涉及 28 名 18 至 30 岁的健康成年人。志愿者被随机分配接受左侧 DLPFC 的兴奋性（间歇性 [iTBS]）、抑制性（连续 TBS [cTBS]）或假刺激。使用 ERP（听觉古怪范式 P300）和神经心理学测试（Trail making test [TMT] 和 Stroop test of words and colours [STWC]），使用前后刺激方案对受试者进行评估。结果：抑制性刺激导致 P300 峰值潜伏期显着延迟 ( p #x3c; 0.001)，N2P3 幅度没有一致的变化。cTBS 也显着影响了 Stroop C 和 Stroop 干扰（p= 0.025）与 iTBS 和假组相比。TBS 后 TMT 测试未发现显着结果。结论：我们的结果表明 P300 和特定的 Stroop 颜色和单词测试参数可以类似地受到相同 TBS 协议的影响。这强调了在与使用经颅磁刺激和认知相关的研究中使用神经心理学和神经生理学资源进行混合评估的重要性。
神经心理生物学