Abstract Cirrhosis caused by viral and alcoholic hepatitis is an essential cause of portal hypertension (PHT). The incidence of PHT complication is directly proportional to portal venous pressure (PVP), and the clinical research of PVP and its hemodynamic indexes is of great significance for deciding the treatment strategy of PHT. Various techniques are currently being developed to decrease portal pressure but hemodynamic side effects may occur. In this article, the hemodynamic indexes of cirrhotic PHT patients were studied to explore the correlation between the index and PVP and to evaluate the clinical value of Doppler ultrasound in measuring PVP in patients with PHT. This was achieved by selecting 90 cirrhotic PHT patients who underwent transjugular intrahepatic portosystemic shunt in our hospital from June 2015 to September 2019. Fifty healthy people who had a physical examination in the hospital in the same period were selected as the control group. The liver hemodynamic parameters of two groups were measured by Doppler ultrasound, and the cirrhotic PHT patients were graded by the Child–Pugh grading method to evaluate the liver function and measure the PVP value. The results showed that both the central portal vein velocity (PVV) and splenic vein velocity (SVV) of the PHT group were lower than those of the control group. Also, the portal vein diameter (PVD), portal venous flow and splenic vein diameter (SVD) were higher than those of the control group (all Ps < 0.05). Among liver function graded PHT patients, the PVD, PVV, SVD and SVV were significantly different (all Ps < 0.05). Furthermore, the PVP of patients with liver function grades A, B and C was 38.9 ± 1.4, 40.6 ± 5.1 and 42.5 ± 4.8 cmH2O, respectively, with a significant difference. It can be concluded from this study that Doppler ultrasound can be used as a tool for clinical assessment of PHT in cirrhosis patients. Doppler ultrasound showed a good prospect in noninvasive detection of PHT in cirrhosis; however, this technique needs application on large sample population study to validate the results.

中文翻译：

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肝硬化门脉高压患者血流动力学参数与门静脉压力的关系

摘要 病毒性和酒精性肝炎引起的肝硬化是门静脉高压症（PHT）的重要原因。PHT并发症的发生率与门静脉压（PVP）成正比，PVP及其血流动力学指标的临床研究对决定PHT的治疗策略具有重要意义。目前正在开发各种技术来降低门静脉压力，但可能会出现血液动力学副作用。本文通过研究肝硬化PHT患者血流动力学指标,探讨该指标与PVP的相关性,评价多普勒超声在PHT患者PVP测量中的临床价值。这是通过选择2015年6月至2019年9月在我院接受经颈静脉肝内门体分流术的90例肝硬化PHT患者实现的。选取同期在医院进行体检的健康人50人作为对照组。采用多普勒超声测量两组肝血流动力学参数,采用Child-Pugh分级法对肝硬化PHT患者进行分级,评价肝功能并测量PVP值。结果显示，PHT组门静脉中心静脉流速（PVV）和脾静脉流速（SVV）均低于对照组。此外，门静脉直径（PVD）、门静脉血流和脾静脉直径（SVD）均高于对照组（所有 Ps < 0.05）。肝功能分级PHT患者中，PVD、PVV、SVD和SVV差异显着（P均<0.05）。此外，肝功能A、B、C级患者的PVP为38.9±1.4，分别为 40.6 ± 5.1 和 42.5 ± 4.8 cmH2O，差异显着。本研究可以得出结论，多普勒超声可作为肝硬化患者PHT临床评估的工具。多普勒超声在肝硬化PHT的无创检测中显示出良好的前景；然而，该技术需要应用于大样本人群研究以验证结果。