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It’s Not Easy Being Green: A Narrative Review on the Microbiology, Virulence and Therapeutic Prospects of Multidrug-Resistant Pseudomonas aeruginosa
Antibiotics ( IF 4.8 ) Pub Date : 2021-01-04 , DOI: 10.3390/antibiotics10010042
Payam Behzadi 1 , Zoltán Baráth 2 , Márió Gajdács 3, 4
Affiliation  

Pseudomonas aeruginosa is the most frequent cause of infection among non-fermenting Gram-negative bacteria, predominantly affecting immunocompromised patients, but its pathogenic role should not be disregarded in immunocompetent patients. These pathogens present a concerning therapeutic challenge to clinicians, both in community and in hospital settings, due to their increasing prevalence of resistance, and this may lead to prolonged therapy, sequelae, and excess mortality in the affected patient population. The resistance mechanisms of P. aeruginosa may be classified into intrinsic and acquired resistance mechanisms. These mechanisms lead to occurrence of resistant strains against important antibiotics—relevant in the treatment of P. aeruginosa infections—such as β-lactams, quinolones, aminoglycosides, and colistin. The occurrence of a specific resistotype of P. aeruginosa, namely the emergence of carbapenem-resistant but cephalosporin-susceptible (Car-R/Ceph-S) strains, has received substantial attention from clinical microbiologists and infection control specialists; nevertheless, the available literature on this topic is still scarce. The aim of this present review paper is to provide a concise summary on the adaptability, virulence, and antibiotic resistance of P. aeruginosa to a readership of basic scientists and clinicians.

中文翻译:

绿色不易:多重耐药铜绿假单胞菌的微生​​物学、毒力和治疗前景的叙述性回顾

铜绿假单胞菌是非发酵革兰氏阴性菌中最常见的感染原因,主要影响免疫功能低下的患者,但其在免疫功能正常的患者中的致病作用不应被忽视。这些病原体对社区和医院环境中的临床医生提出了令人担忧的治疗挑战,因为它们的耐药性不断增加,这可能导致受影响患者群体的治疗时间延长、后遗症和死亡率过高。铜绿假单胞菌的耐药机制可分为内在耐药机制和获得性耐药机制。这些机制导致出现针对与治疗铜绿假单胞菌感染相关的重要抗生素(例如β-内酰胺类、喹诺酮类、氨基糖苷类和粘菌素)的耐药菌株。铜绿假单胞菌特定耐药型的出现,即碳青霉烯类耐药但头孢菌素敏感(Car-R/Ceph-S)菌株的出现,引起了临床微生物学家和感染控制专家的广泛关注;然而,关于这一主题的现有文献仍然很少。本文的目的是向基础科学家和临床医生的读者提供关于铜绿假单胞菌的适应性、毒力和抗生素耐药性的简明总结。
更新日期:2021-01-04
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