The Cover Feature shows the application of aqueous polysulfide solutions in the chromatography‐free multicomponent synthesis of thioureas. We have used a large pool of bases to cleave the octasulfur ring generating water‐soluble, zwitterionic polsulfide chains. Using these aqueous solutions as sulfurating agents, we were able to omit the otherwise mandatory chromatography to separate the organic products from the excess of sulfur. The methodology has been validated in a wide range of synthesis scenarios highlighting challenging biaryl derivatives and the marketed drug, thiocarlide. More information can be found in the Full Paper by András Gy. Németh et al.

中文翻译：

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封面人物：元素硫水溶液可实现无色谱多组分合成硫脲（ChemistryOpen 1/2021）

封面功能显示了多硫化物水溶液在无色谱的硫脲多组分合成中的应用。我们使用了大量的碱基来裂解八硫环，从而生成水溶性的两性离子聚硫化物链。使用这些水溶液作为硫化剂，我们可以省去否则必须进行的色谱分离，以将有机产物与过量的硫分离。该方法已在广泛的合成方案中得到了验证，这些方案突出了具有挑战性的联芳基衍生物和市售药物硫代羧化物。可以在AndrásGy的《全文》中找到更多信息。Németh等。