Tetrazole carboxamide is one of the important categories of heterocyclic compounds that acquire a broad spectrum of biological and medicinal properties. The present work deals with the synthesis and characterization of some novel 1-aryl-N-tosyl-1H-tetrazole-5-carboxamide derivatives. All the synthesized compounds were characterized by FT-IR, ¹HNMR, ¹³CNMR, elemental and mass spectrometric analysis. The compounds were evaluated for their in-vitro and in-vivo anti-diabetic and antimicrobial activity. Synthesized compound 3i 10 mg/kg exhibited maximum glucose lowering effect in diabetic rats compared to the other ten doses. All the synthesized compounds were evaluated in ADME properties and in-silico docking studies against proteins (PDB code-1E7U, 3KP3).

四唑甲酰胺是重要的杂环化合物类别之一，具有广泛的生物学和医学特性。本工作涉及一些新型的1-芳基-N-甲苯磺酰基-1H-四唑-5-羧酰胺衍生物的合成和表征。所有合成的化合物通过FT-IR，¹ HNMR，¹³ CNMR，元素和质谱分析进行表征。评价化合物的体外和体内抗糖尿病和抗微生物活性。合成化合物3i与其他十剂相比，10 mg / kg在糖尿病大鼠中表现出最大的葡萄糖降低作用。所有合成的化合物均经过ADME性能评估和针对蛋白质（PDB代码1E7U，3KP3）的计算机对接研究。