Epilepsy is a devastating neurological disorder characterized by the repeated occurrence of epileptic seizures. Epilepsy stands as a global health concern affecting around 70 million people worldwide. The mainstream antiepileptic drugs (AEDs) only exert symptomatic relief and drug-resistant epilepsy occurs in up to 33 percent of patients. Hence, the investigation of novel therapeutic strategies against epileptic seizures that could exert disease modifying effects is of paramount importance. In this context, compounds of natural origin with potential antiepileptic properties have recently gained increasing attention. Quercetin is a plant-derived flavonoid with several pharmacological activities. Emerging evidence has demonstrated the antiepileptic potential of quercetin as well. Herein, based on the available evidence, we discuss the neuroprotective effects of quercetin against epileptic seizures and further analyze the plausible underlying molecular mechanisms. Our review suggests that quercetin might be a potential therapeutic candidate against epilepsy that deserves further investigation, and paves the way for the development of plant-derived antiepileptic treatment approaches.

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阐明槲皮素在癫痫中的神经保护作用：从机制到治疗机会

癫痫是一种破坏性的神经系统疾病，其特征是癫痫发作的反复发生。癫痫是一个全球性的健康问题，影响着全世界约 7000 万人。主流抗癫痫药物 (AED) 只能缓解症状，高达 33% 的患者会发生耐药性癫痫。因此，研究可以发挥疾病修饰作用的针对癫痫发作的新治疗策略至关重要。在这种情况下，具有潜在抗癫痫特性的天然来源的化合物最近受到越来越多的关注。槲皮素是一种植物来源的黄酮类化合物，具有多种药理活性。新出现的证据也证明了槲皮素的抗癫痫潜力。在此，根据现有证据，我们讨论了槲皮素对癫痫发作的神经保护作用，并进一步分析了可能的潜在分子机制。我们的综述表明，槲皮素可能是一种潜在的癫痫治疗候选药物，值得进一步研究，并为开发植物源性抗癫痫治疗方法铺平了道路。