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The number of anti-seizure medications mediates the relationship between cognitive performance and quality of life in temporal lobe epilepsy
Epilepsy & Behavior ( IF 2.6 ) Pub Date : 2021-02-01 , DOI: 10.1016/j.yebeh.2020.107699
Alejandro Lozano-García , Kevin G. Hampel , Vicente Villanueva , Esperanza González-Bono , Irene Cano-López

OBJECTIVES To assess whether cognitive performance predicts quality of life (QOL) in patients with drug-resistant temporal lobe epilepsy (TLE), using the Epitrack cognitive screening tool, while considering the mediating role of the number of anti-seizure medications (ASMs) and controlling for seizure-related, social, and emotional factors. METHODS Seventy-five adult patients with drug-resistant TLE (mean age = 39.76 years, SD = 11.66) underwent a presurgical neuropsychological assessment. MAIN OUTCOME MEASURES Cognitive performance (Epitrack), depression (BDI-II), trait anxiety (STAI); and QOL (QOLIE-31) were assessed. RESULTS Adjusting for seizure-related, social, and emotional factors, the Epitrack total score significantly contributed to QOL composite score, and energy and cognitive self-rating subscales. We found a significant indirect effect of the Epitrack total score on QOL composite score and seizure worry and social functioning subscales via the number of ASMs. CONCLUSION Our findings underline the relevance of cognitive functioning on QOL and the clinical utility of Epitrack to track cognitive side effects of ASMs and, consequently, to predict and manage QOL in this population.

中文翻译:

抗癫痫药物的数量介导颞叶癫痫认知能力与生活质量的关系

目的 使用 Epitrack 认知筛查工具评估认知表现是否能预测耐药性颞叶癫痫 (TLE) 患者的生活质量 (QOL),同时考虑抗癫痫药物 (ASM) 和控制与癫痫有关的、社会和情绪因素。方法 75 名患有耐药性 TLE 的成年患者(平均年龄 = 39.76 岁,SD = 11.66)接受了术前神经心理学评估。主要结果测量认知表现 (Epitrack)、抑郁 (BDI-II)、特质焦虑 (STAI);和 QOL (QOLIE-31) 进行了评估。结果 调整癫痫相关、社会和情绪因素后,Epitrack 总分对 QOL 综合评分、能量和认知自评分量表有显着贡献。我们发现 Epitrack 总分通过 ASM 的数量对 QOL 综合评分和癫痫发作担忧和社会功能分量表有显着的间接影响。结论我们的研究结果强调了认知功能与 QOL 的相关性以及 Epitrack 的临床效用,以跟踪 ASM 的认知副作用,从而预测和管理该人群的 QOL。
更新日期:2021-02-01
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