Background

Human immunodeficiency virus-1 (HIV-1) infected people are more likely to develop tuberculosis (TB), being the leading cause of death in HIV-1. Candida spp has emerged as potential pathogenic fungi in patients with HIV and bronchopulmonary diseases. This systematic review summarizes the available data on the occurrence of oral candidiasis (OC) in the HIV-1/pulmonary tuberculosis (pTB) coinfection.

Methods

Articles that reported the occurrence of OC in the HIV-1-pTB coinfection were searched in eight databases. Observational studies that evaluated the association between OC and HIV-1-pTB coinfection were selected. The risk of bias was assessed using the meta-analysis of statistics assessment and review instrument (MAStARI) checklist.

Results

From a total of 1858 records, after application of inclusion and exclusion criteria, six were included in the meta-analysis. Three studies were at low risk, one at moderate risk, and two at high risk of bias. Considerable heterogeneity across the studies was identified. Meta-analyses performed showed no difference in the prevalence of OC between HIV-1 patients with and without pTB coinfection (odds ratio M-H = 1.77; 95% CI = 0.69 to 4.52).

Conclusion

There is no association between OC and HIV-1/pTB coinfection.

PROSPERO registration number

CRD42019128735.

中文翻译：

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人免疫缺陷病毒-1和肺结核合并感染中的口腔念珠菌病患病率：系统评价和荟萃分析

背景

感染人类免疫缺陷病毒1（HIV-1）的人更容易患上结核病（TB），这是HIV-1死亡的主要原因。念珠菌已成为HIV和支气管肺病患者的潜在致病真菌。该系统综述总结了HIV-1 /肺结核（pTB）合并感染中口腔念珠菌病（OC）发生的可用数据。

方法

在8个数据库中搜索了报道HIV-1-pTB合并感染中OC发生的文章。选择观察性研究来评估OC和HIV-1-pTB合并感染之间的关联。使用统计评估和审查工具（MAStARI）的荟萃分析评估偏倚的风险。

结果

从总共1858条记录中，应用纳入标准和排除标准后，荟萃分析包括了6项。三项研究的风险较低，一项为中度风险，两项为偏倚风险较高。在研究中发现了相当大的异质性。进行的荟萃分析显示，在有和没有pTB合并感染的HIV-1患者中，OC的患病率没有差异（优势比MH = 1.77； 95％CI = 0.69至4.52）。

结论

OC与HIV-1 / pTB合并感染之间没有关联。

PROSPERO注册号

CRD42019128735。