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Good pyridine hunting: a biomimic compound, a modifier and a unique pharmacophore in agrochemicals
Chemistry of Heterocyclic Compounds ( IF 1.5 ) Pub Date : 2021-01-04 , DOI: 10.1007/s10593-020-02843-w
Vladimir V. Zakharychev , Aleksandr V. Kuzenkov , Andrey M. Martsynkevich

95 agrochemical products have been described based on the pyridine scaffold making it the most commercially successful heterocycle in the synthesis of plant protection chemicals in the 21st century. The pyridine fragment is capable of modifying the properties of compounds, sometimes changing their application, and can be a unique pharmacophore. When possible, the relationship of pyridine analogs with carbocyclic or aliphatic precursors is shown. The mechanism of action of the compounds is described, if known. Examples of syntheses of pyridine intermediates used in the manufacture of agrochemicals are given.



中文翻译:

良好的吡啶捕集:农药中的仿生化合物,修饰剂和独特的药效团

已经描述了基于吡啶骨架的95种农用化学产品,使其成为21世纪植物保护化学合成中商业上最成功的杂环。吡啶片段能够修饰化合物的性质,有时会改变其应用,并且可以是独特的药效团。可能时,显示吡啶类似物与碳环或脂族前体的关系。如果已知,将描述化合物的作用机理。给出了用于农业化学生产中的吡啶中间体的合成实例。

更新日期:2021-01-04
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