Abstract

Ionic liquid (IL)-assisted Co₃O₄ nanostructures were synthesized by a simple, facile and novel low-temperature aqueous chemical growth method and used for the modification of glassy carbon electrode (GCE) for the selective determination of ascorbic acid (AA). Different volumes of IL were used in the preparation of nanostructures to examine the effect of IL on the morphology and electrochemical performance of the synthesized material. The functionalities of the prepared material were investigated by FTIR, while the crystalline nature and phase purity of the material were confirmed by XRD results. FESEM analysis were carried out to expose the surface characteristics of the prepared nanostructures and the results demonstrated that the cobalt oxide nanostructures possess nanorods like morphology. The EDX results verified the maximum elemental percent composition for the cobalt and oxygen in the synthesized material. The electrochemical performance of Co₃O₄ nanostructures modified GCE was investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The electrochemical results demonstrated that the modified electrode shown outstanding performance in the determination of AA with a very low limit of detection (1 µM) along with higher stability and repeatability features. The novel AA sensor manifested exceptional sensitivity and selectivity over a wide linear range of concentration from 0.05 to 3 mM with the coefficient of determination R² = 0.998. The applicability of the developed sensor was examined in the pharmaceutical samples that contain AA and the sensor selectively detected the AA from multiple ingredients that were present in their formulation with acceptable recovery.

Graphic abstract

It describes the synthesis of [BMIM][PF₆] IL functionalized cobalt oxide nanostructures through low-temperature aqueous chemical growth method and the synthesized material was utilized to fabricate an electrochemical sensor (Co₃O₄/GCE) for the selective determination of Ascorbic acid.

中文翻译：

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基于功能性Co 3 O 4纳米结构的电化学传感器直接测定药物样品中的抗坏血酸

摘要

离子液体（IL）辅助的Co ₃ O ₄纳米结构是通过简单，便捷和新颖的低温水化学生长方法合成的，并用于修饰玻碳电极（GCE）以选择性测定抗坏血酸（AA）。不同体积的IL用于制备纳米结构，以检查IL对合成材料的形态和电化学性能的影响。通过FTIR研究了所制备材料的功能性，而通过XRD结果证实了该材料的结晶性质和相纯度。进行FESEM分析以暴露所制备的纳米结构的表面特征，结果表明，氧化钴纳米结构具有像形态的纳米棒。EDX结果证实了合成材料中钴和氧的最大元素百分含量。Co的电化学性能通过循环伏安法（CV）和电化学阻抗谱（EIS）研究了₃ O ₄纳米结构修饰的GCE。电化学结果表明，修饰电极在AA的测定中表现出卓越的性能，具有极低的检测限（1 µM），以及更高的稳定性和可重复性。新型AA传感器在浓度范围为0.05至3 mM的宽线性范围内表现出出众的灵敏度和选择性，测定系数R ²  = 0.998。在包含AA的药物样品中检查了开发的传感器的适用性，并且该传感器从其制剂中存在的多种成分中选择性检测了AA，回收率令人满意。

图形摘要

它描述了通过低温水性化学生长方法合成[BMIM] [PF ₆ ] IL功能化的氧化钴纳米结构，并利用合成的材料制备了电化学传感器（Co ₃ O ₄ / GCE），用于选择性测定抗坏血酸酸。