The 2021 Nucleic Acids Research database Issue contains 189 papers spanning a wide range of biological fields and investigation. It includes 89 papers reporting on new databases and 90 covering recent changes to resources previously published in the Issue. A further ten are updates on databases most recently published elsewhere. Seven new databases focus on COVID-19 and SARS-CoV-2 and many others offer resources for studying the virus. Major returning nucleic acid databases include NONCODE, Rfam and RNAcentral. Protein family and domain databases include COG, Pfam, SMART and Panther. Protein structures are covered by RCSB PDB and dispersed proteins by PED and MobiDB. In metabolism and signalling, STRING, KEGG and WikiPathways are featured, along with returning KLIFS and new DKK and KinaseMD, all focused on kinases. IMG/M and IMG/VR update in the microbial and viral genome resources section, while human and model organism genomics resources include Flybase, Ensembl and UCSC Genome Browser. Cancer studies are covered by updates from canSAR and PINA, as well as newcomers CNCdatabase and Oncovar for cancer drivers. Plant comparative genomics is catered for by updates from Gramene and GreenPhylDB. The entire Database Issue is freely available online on the Nucleic Acids Research website (https://academic.oup.com/nar). The NAR online Molecular Biology Database Collection has been substantially updated, revisiting nearly 1000 entries, adding 90 new resources and eliminating 86 obsolete databases, bringing the current total to 1641 databases. It is available at https://www.oxfordjournals.org/nar/database/c/.

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2021年核酸研究数据库期刊及在线分子生物学数据库合集

2021 年核酸研究数据库期刊包含 189 篇论文，涵盖广泛的生物领域和研究。它包括 89 篇关于新数据库的论文，90 篇涵盖本期先前发布的资源的最新变化。另外十个是最近在其他地方发布的数据库的更新。七个新数据库专注于 COVID-19 和 SARS-CoV-2，还有许多其他数据库提供了研究该病毒的资源。主要返回的核酸数据库包括 NONCODE、Rfam 和 RNAcentral。蛋白质家族和域数据库包括 COG、Pfam、SMART 和 Panther。RCSB PDB 涵盖蛋白质结构，PED 和 MobiDB 涵盖分散蛋白质。在代谢和信号传导方面，STRING、KEGG 和 WikiPathways 占据重要地位，此外还有回归的 KLIFS 以及新的 DKK 和 KinaseMD，所有这些都专注于激酶。IMG/M 和 IMG/VR 更新了微生物和病毒基因组资源部分，而人类和模式生物基因组学资源包括 Flybase、Ensembl 和 UCSC Genome Browser。canSAR 和 PINA 以及针对癌症驱动因素的新产品 CNCdatabase 和 Oncovar 的更新涵盖了癌症研究。Gramene 和 GreenPhylDB 的更新满足了植物比较基因组学的需求。整个数据库问题可在核酸研究网站 (https://academic.oup.com/nar) 上免费在线获取。NAR 在线分子生物学数据库集已大幅更新，重新访问了近 1000 个条目，添加了 90 个新资源并消除了 86 个过时的数据库，使当前数据库总数达到 1641 个。可在 https://www.oxfordjournals.org/nar/database/c/ 获取。