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MarkerDB: an online database of molecular biomarkers
Nucleic Acids Research ( IF 14.9 ) Pub Date : 2020-11-27 , DOI: 10.1093/nar/gkaa1067
David S Wishart 1, 2, 3, 4 , Brendan Bartok 1 , Eponine Oler 1 , Kevin Y H Liang 1 , Zachary Budinski 1 , Mark Berjanskii 1 , AnChi Guo 1 , Xuan Cao 1 , Michael Wilson 1, 5
Affiliation  

Abstract
MarkerDB is a freely available electronic database that attempts to consolidate information on all known clinical and a selected set of pre-clinical molecular biomarkers into a single resource. The database includes four major types of molecular biomarkers (chemical, protein, DNA [genetic] and karyotypic) and four biomarker categories (diagnostic, predictive, prognostic and exposure). MarkerDB provides information such as: biomarker names and synonyms, associated conditions or pathologies, detailed disease descriptions, detailed biomarker descriptions, biomarker specificity, sensitivity and ROC curves, standard reference values (for protein and chemical markers), variants (for SNP or genetic markers), sequence information (for genetic and protein markers), molecular structures (for protein and chemical markers), tissue or biofluid sources (for protein and chemical markers), chromosomal location and structure (for genetic and karyotype markers), clinical approval status and relevant literature references. Users can browse the data by conditions, condition categories, biomarker types, biomarker categories or search by sequence similarity through the advanced search function. Currently, the database contains 142 protein biomarkers, 1089 chemical biomarkers, 154 karyotype biomarkers and 26 374 genetic markers. These are categorized into 25 560 diagnostic biomarkers, 102 prognostic biomarkers, 265 exposure biomarkers and 6746 predictive biomarkers or biomarker panels. Collectively, these markers can be used to detect, monitor or predict 670 specific human conditions which are grouped into 27 broad condition categories. MarkerDB is available at https://markerdb.ca.


中文翻译:

MarkerDB:分子生物标志物的在线数据库

摘要
MarkerDB是一个免费的电子数据库,它试图将所有已知临床信息和一组选定的临床前分子生物标志物信息整合到一个资源中。该数据库包括四种主要类型的分子生物标记(化学,蛋白质,DNA [遗传]和核型)和四种生物标记类别(诊断,预测,预后和暴露)。MarkerDB提供的信息包括:生物标志物名称和同义词,相关条件或病理,详细的疾病描述,详细的生物标志物描述,生物标志物特异性,敏感性和ROC曲线,标准参考值(对于蛋白质和化学标志物),变体(对于SNP或遗传标志物) ),序列信息(用于遗传和蛋白质标记),分子结构(用于蛋白质和化学标记),组织或生物流体来源(用于蛋白质和化学标记),染色体的位置和结构(用于遗传和核型标记),临床批准状态和相关文献参考。用户可以按条件,条件类别,生物标志物类型,生物标志物类别浏览数据,也可以通过高级搜索功能按序列相似性进行搜索。目前,该数据库包含142个蛋白质生物标记,1089个化学生物标记,154个核型生物标记和26374个遗传标记。这些分类为25 560个诊断生物标志物,102个预后生物标志物,265个暴露生物标志物和6746个预测生物标志物或生物标志物组。这些标记可共同用于检测,监视或预测670种特定人类疾病,这些疾病分为27大疾病类别。MarkerDB可在https:
更新日期:2021-01-03
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