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Mouse Genome Database (MGD): Knowledgebase for mouse–human comparative biology
Nucleic Acids Research ( IF 14.9 ) Pub Date : 2020-11-24 , DOI: 10.1093/nar/gkaa1083
Judith A Blake 1 , Richard Baldarelli 1 , James A Kadin 1 , Joel E Richardson 1 , Cynthia L Smith 1 , Carol J Bult 1 ,
Affiliation  

Abstract
The Mouse Genome Database (MGD; http://www.informatics.jax.org) is the community model organism knowledgebase for the laboratory mouse, a widely used animal model for comparative studies of the genetic and genomic basis for human health and disease. MGD is the authoritative source for biological reference data related to mouse genes, gene functions, phenotypes and mouse models of human disease. MGD is the primary source for official gene, allele, and mouse strain nomenclature based on the guidelines set by the International Committee on Standardized Nomenclature for Mice. MGD’s biocuration scientists curate information from the biomedical literature and from large and small datasets contributed directly by investigators. In this report we describe significant enhancements to the content and interfaces at MGD, including (i) improvements in the Multi Genome Viewer for exploring the genomes of multiple mouse strains, (ii) inclusion of many more mouse strains and new mouse strain pages with extended query options and (iii) integration of extensive data about mouse strain variants. We also describe improvements to the efficiency of literature curation processes and the implementation of an information portal focused on mouse models and genes for the study of COVID-19.


中文翻译:

小鼠基因组数据库 (MGD):小鼠-人类比较生物学知识库

摘要
小鼠基因组数据库(MGD;http://www.informatics.jax.org)是实验室小鼠的群落模型生物知识库,是一种广泛使用的动物模型,用于人类健康和疾病的遗传和基因组基础的比较研究。MGD 是与小鼠基因、基因功能、表型和人类疾病小鼠模型相关的生物参考数据的权威来源。MGD 是根据国际小鼠标准化命名委员会制定的指南制定的官方基因、等位基因和小鼠品系命名法的主要来源。MGD 的生物管理科学家从生物医学文献以及研究人员直接贡献的大大小小的数据集中整理信息。在本报告中,我们描述了 MGD 内容和界面的显着增强,包括 (i) 用于探索多种小鼠品系基因组的多基因组查看器的改进,(ii) 包含更多小鼠品系和具有扩展功能的新小鼠品系页面。查询选项和(iii)整合有关小鼠品系变异的大量数据。我们还描述了文献管理流程效率的改进以及专注于用于研究 COVID-19 的小鼠模型和基因的信息门户的实施。
更新日期:2021-01-03
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