Abstract

For more than two decades, the UCSC Genome Browser database (https://genome.ucsc.edu) has provided high-quality genomics data visualization and genome annotations to the research community. As the field of genomics grows and more data become available, new modes of display are required to accommodate new technologies. New features released this past year include a Hi-C heatmap display, a phased family trio display for VCF files, and various track visualization improvements. Striving to keep data up-to-date, new updates to gene annotations include GENCODE Genes, NCBI RefSeq Genes, and Ensembl Genes. New data tracks added for human and mouse genomes include the ENCODE registry of candidate cis-regulatory elements, promoters from the Eukaryotic Promoter Database, and NCBI RefSeq Select and Matched Annotation from NCBI and EMBL-EBI (MANE). Within weeks of learning about the outbreak of coronavirus, UCSC released a genome browser, with detailed annotation tracks, for the SARS-CoV-2 RNA reference assembly.

中文翻译：

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UCSC基因组浏览器数据库：2021年更新

摘要

二十多年来，UCSC基因组浏览器数据库（https://genome.ucsc.edu）为研究界提供了高质量的基因组数据可视化和基因组注释。随着基因组学领域的发展和更多数据的可用，需要新的显示方式来适应新技术。去年发布的新功能包括Hi-C热图显示，用于VCF文件的分阶段家庭三重奏显示以及各种轨道可视化改进。为了使数据保持最新，对基因注释的新更新包括GENCODE基因，NCBI RefSeq基因和Ensembl基因。为人类和小鼠基因组添加的新数据包括候选顺式调控元件的ENCODE注册表，真核启动子数据库的启动子以及NCBI和EMBL-EBI（MANE）的NCBI RefSeq选择和匹配注释。