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RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences
Nucleic Acids Research ( IF 14.9 ) Pub Date : 2020-11-19 , DOI: 10.1093/nar/gkaa1038
Stephen K Burley 1, 2, 3, 4, 5 , Charmi Bhikadiya 1, 2 , Chunxiao Bi 4 , Sebastian Bittrich 4 , Li Chen 1, 2 , Gregg V Crichlow 1, 2 , Cole H Christie 4 , Kenneth Dalenberg 1, 2 , Luigi Di Costanzo 1, 2 , Jose M Duarte 4 , Shuchismita Dutta 1, 2, 3 , Zukang Feng 1, 2 , Sai Ganesan 6 , David S Goodsell 1, 2, 7 , Sutapa Ghosh 1, 2 , Rachel Kramer Green 1, 2 , Vladimir Guranović 1, 2 , Dmytro Guzenko 4 , Brian P Hudson 1, 2 , Catherine L Lawson 1, 2 , Yuhe Liang 1, 2 , Robert Lowe 1, 2 , Harry Namkoong 1, 2 , Ezra Peisach 1, 2 , Irina Persikova 1, 2 , Chris Randle 4 , Alexander Rose 4 , Yana Rose 4 , Andrej Sali 6 , Joan Segura 4 , Monica Sekharan 1, 2 , Chenghua Shao 1, 2 , Yi-Ping Tao 1, 2 , Maria Voigt 1, 2 , John D Westbrook 1, 2, 3 , Jasmine Y Young 1, 2 , Christine Zardecki 1, 2 , Marina Zhuravleva 1, 2
Affiliation  

Abstract
The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB), the US data center for the global PDB archive and a founding member of the Worldwide Protein Data Bank partnership, serves tens of thousands of data depositors in the Americas and Oceania and makes 3D macromolecular structure data available at no charge and without restrictions to millions of RCSB.org users around the world, including >660 000 educators, students and members of the curious public using PDB101.RCSB.org. PDB data depositors include structural biologists using macromolecular crystallography, nuclear magnetic resonance spectroscopy, 3D electron microscopy and micro-electron diffraction. PDB data consumers accessing our web portals include researchers, educators and students studying fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences. During the past 2 years, the research-focused RCSB PDB web portal (RCSB.org) has undergone a complete redesign, enabling improved searching with full Boolean operator logic and more facile access to PDB data integrated with >40 external biodata resources. New features and resources are described in detail using examples that showcase recently released structures of SARS-CoV-2 proteins and host cell proteins relevant to understanding and addressing the COVID-19 global pandemic.


中文翻译:

RCSB 蛋白质数据库:用于探索生物大分子 3D 结构的强大新工具,用于基础生物学、生物医学、生物技术、生物工程和能源科学的基础和应用研究和教育

摘要
结构生物信息学蛋白质数据库 (RCSB PDB) 研究合作实验室是全球 PDB 档案的美国数据中心,也是全球蛋白质数据库合作伙伴关系的创始成员,为美洲和大洋洲的数万名数据存储者提供服务,并制作 3D大分子结构数据免费且不受限制地提供给全球数百万 RCSB.org 用户,其中包括超过 660 000 名使用 PDB101.RCSB.org 的教育工作者、学生和好奇的公众成员。PDB 数据存储者包括使用大分子晶体学、核磁共振光谱、3D 电子显微镜和微电子衍射的结构生物学家。访问我们门户网站的 PDB 数据消费者包括研究基础生物学、生物医学、生物技术、生物工程和能源科学。在过去的 2 年中,以研究为中心的 RCSB PDB 门户网站 (RCSB.org) 进行了彻底的重新设计,通过完整的布尔运算符逻辑改进了搜索,并更轻松地访问了与 40 多个外部生物数据资源集成的 PDB 数据。使用示例详细描述了新功能和资源,这些示例展示了与理解和应对 COVID-19 全球大流行相关的最近发布的 SARS-CoV-2 蛋白和宿主细胞蛋白的结构。
更新日期:2021-01-03
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