The purpose of the study was to evaluate the protective effects of polygonatum sibiricum polysaccharide (PP), an important component of rhizome polygonatum, on cyclophosphamide (CY) induced immunosuppressed chickens. Four hundred and eighty one-day-old Erlang mountainous chickens were randomly allocated into four treatments. The main factors consisted of dietary supplement (PP at 0 or 800 mg/kg of diet) and immunosuppressive challenge (birds challenged with CY or treated with sterile saline). The results showed that PP enhanced chickens' growth performance via elevating daily weight gain (DWG), serum protein production, and decreasing feed conversion ratio (FCR). Moreover, physical measurements revealed that PP accelerated recovery of relative weights of immune organs and maintained their structure and function. Biochemical analysis indicated that PP significantly stimulated immunoglobulin and antioxidant indexes in serum, and improved the proliferation of peripheral blood T lymphocytes. In addition, PP promoted immune organs cells to enter into S and G₂/M phases as well as inhibited the apoptosis in the spleen, thymus, and bursa of Fabricius. PP up regulated the expression of IL-2, IL-6 and IFN-γ genes. Therefore, PP performs a profile in antagonizing Cy-induced immunosuppression in chickens, and it seems that PP can be used as a potential immunostimulant agent.

该研究的目的是评估玉竹的保护作用。环磷酰胺（CY）诱导的免疫抑制鸡的多糖（PP），是黄连的重要成分。将480只一天大的二郎山鸡随机分配到四种处理中。主要因素包括膳食补充剂（PP在0或800 mg / kg饲料中）和免疫抑制性攻击（用CY攻击或用无菌盐水处理的鸟）。结果表明，PP通过提高日增重（DWG），提高血清蛋白产量和降低饲料转化率（FCR）来提高鸡的生长性能。此外，物理测量结果表明，PP可以加速免疫器官相对重量的恢复并保持其结构和功能。生化分析表明，PP能显着刺激血清中的免疫球蛋白和抗氧化剂指标，并改善了外周血T淋巴细胞的增殖。此外，PP促进免疫器官细胞进入S和G₂ / M相并抑制Fabricius的脾脏，胸腺和法氏囊中的凋亡。PP上调IL-2，IL-6和IFN-γ基因的表达。因此，PP在拮抗Cy诱导的鸡的免疫抑制方面表现出特征，并且似乎可以将PP用作潜在的免疫刺激剂。