Abstract

A novel series of picarbutrazox-inspired oxadiazole hybrids was synthesized and the derivatives’ biological activity against phytopathogenic fungi was investigated. The molecules were designed by retaining the active fragment of tetrazolyl phenyloxime ether of lead compound picarbutrazox, while introducing the potentially active oxadiazole-derived fragment. Bioassay results revealed that some of the title compounds showed potent in vivo antifungal activities to control cucumber downy mildew. Therefore, this novel oxadiazole phenyloxadiazole derivative can be used as a potential antifungal agent to control cucumber downy mildew and other phytopathogenic fungi for crop protection.

Graphic abstract

中文翻译：

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设计，合成和生物评价苯基恶二唑衍生物作为潜在抗真菌病原真菌的药物

摘要

合成了一系列新的以吡喃唑酮为灵感的恶二唑杂种，并研究了该衍生物对植物致病真菌的生物活性。通过保留铅化合物picarbutrazox的四唑基苯肟醚的活性片段，同时引入可能具有活性的恶二唑衍生片段，来设计分子。生物测定结果表明，某些标题化合物显示出有效的体内抗真菌活性，可控制黄瓜霜霉病。因此，这种新的恶二唑苯基恶二唑衍生物可以用作潜在的抗真菌剂，以控制黄瓜霜霉病和其他植物病原真菌，以保护作物。

图形摘要