Russian Journal of Genetics ( IF 0.6 ) Pub Date : 2021-01-02 , DOI: 10.1134/s1022795420120121 A. Yu. Sambyalova , T. A. Bairova , E. V. Belyaeva , O. A. Ershova , D. S. Sargaeva , S. I. Kolesnikov
Abstract
The allele and genotype frequency distribution at polymorphic loci rs1799853 (430C>T) and rs1057910 (A1075C) of the CYP2C9 gene, rs2108622 (1347C>T) of the CYP4F2 gene, and rs9923231 (1639G>A) of the VKORC1 gene in the Buryat population was examined. The study involved 197 volunteers living in the Republic of Buryatia: 124 woman and 73 men, average age of 57.51 ± 10.88 years. Genetic typing of DNA samples was performed by polymerase chain reaction (RT-PCR). The frequency of the minor alleles *2 and *3 of the CYP2C9 gene was 2.03 and 3.05%, respectively. The frequency of the allele T of the CYP4F2 gene was 31.22%; the frequency of the allele A of the VKORC1 gene was 85.28%. The obtained results could be used in the prognosis of pharmacotherapy of warfarin in the population Buryat population.
中文翻译:
CYP2C9,CYP4F2,VKORC1基因多态性在布里亚特人口
摘要
在多态位点rs1799853(等位基因和基因型频率分布430C>Ť)和rs1057910(A1075C的的)CYP2C9基因,rs2108622(1347C>Ť)所述的CYP4F2基因,和rs9923231(1639G>甲所述的)VKORC1基因在布里亚特检查人口。该研究涉及居住在布里亚特共和国的197名志愿者:124名女性和73名男性,平均年龄为57.51±10.88岁。通过聚合酶链反应(RT-PCR)对DNA样品进行遗传分型。CYP2C9的次要等位基因* 2和* 3的频率基因分别为2.03和3.05%。的等位基因的频率Ť所述的CYP4F2基因为31.22%; 的等位基因的频率甲所述的VKORC1基因为85.28%。所得结果可用于华法林在布里亚特人群中的药物治疗预后。