In Candida albicans, geldanamycin treatment inhibits the essential chaperone Hsp90 and induces a change from yeast to filamentous morphology, likely by impeding cell cycle progression and division. However, filaments formed by wild-type cells upon geldanamycin exposure are quite different in appearance from true hyphae. We have observed that effects on morphology caused by geldanamycin treatment appear to vary in strains with defects in different morphological regulators. These results indicate that the filamentous forms induced by inhibiting Hsp90p, while not true hyphae, nonetheless require some components of the hypha induction machinery for their formation. Furthermore, we have found that BRG1, a known regulator of hypha formation, is also required for pseudohypha induction in response to nitrogen starvation and for the formation of elongated filaments upon exposure to geldanamycin.

在白色念珠菌中，格尔德霉素处理抑制必需的伴侣蛋白 Hsp90 并诱导从酵母到丝状形态的变化，这可能是通过阻碍细胞周期进程和分裂。然而，暴露于格尔德霉素后由野生型细胞形成的细丝在外观上与真正的菌丝有很大不同。我们已经观察到格尔德霉素处理对形态的影响似乎在具有不同形态调节器缺陷的菌株中有所不同。这些结果表明，通过抑制 Hsp90p 诱导的丝状形式虽然不是真正的菌丝，但仍需要菌丝诱导机制的某些成分才能形成。此外，我们发现BRG1已知的菌丝形成调节剂，也是响应氮饥饿诱导假菌丝和暴露于格尔德霉素后形成细长丝所必需的。