In this work, multi-walled carbon nanotubes were applied as sorbent for extraction, followed by back-extraction and HPLC/UV determination of Nalidixic acid in aqueous solutions. The effects of some parameters such as pH, flow velocity, sorbent amount, and ionic strength were investigated. A little amount of sorbent (5.0 mg) was chosen as its optimum amount which this sorbent was reusable for almost five cycles of adsorption/desorption processes. A preconcentration factor of 500 was obtained. Linear range was 0.19–23.2 mg L⁻¹ (R² = 0.9979). The limit of detection and RSD for the suggested method were 0.02 mg L⁻¹ and 2.2%, respectively. To assess the method performance for real samples, Nalidixic acid was determined in human blood serum and tablet samples. Advantages of the suggested method for Nalidixic acid extraction and preconcentration are low cost, being less time consuming, simplicity, no usage of organic solvents, and high preconcentration factor and efficiency.

在这项工作中，将多壁碳纳米管用作吸附剂进行萃取，然后进行反萃取，并通过HPLC / UV测定水溶液中的萘啶酸。研究了诸如pH，流速，吸附量和离子强度等参数的影响。选择少量的吸附剂（5.0 mg）作为最佳吸附剂，该吸附剂可重复用于几乎五个吸附/解吸过程。获得的预浓缩系数为500。线性范围为0.19–23.2 mg L ^-1（R ² = 0.9979）。建议方法的检测限和RSD为0.02 mg L ^-1和2.2％。为了评估实际样品的方法性能，在人血清和片剂样品中测定了萘啶酸。所建议的萘啶酸提取和预浓缩方法的优点是成本低，耗时少，简单，不使用有机溶剂，预浓缩系数和效率高。