In recent years, metal oxides have been studied as an encapsulating matrix nevertheless, few studies the effect that can exist between different precursors to form this type of nanomaterials; In this paper, we compare its ability as a mangiferin (MG) nanoencapsulated. Phytochemical that has been studied for its generous biological properties like anti-inflammatory, antiproliferative, and others; the nanoparticles (NP’s) be synthesized with zinc nitrate and zinc acetate. The results showed modifications in the morphology of the ZnO associated with the precursor but, there is no significant difference between any treatment that is associated with antitopoisomerase activity however, ZnO_A-MG is statistically the best treatment by reducing in greater proportion the production of COX-II prostaglandins (97.38 ± 7.09%) with a significant difference (p < 0.05) compared toCOX-I (68.02 ± 2.14%) but, it is not considered a selective treatment moreover ZnO_A-MG proved to be the least hepatotoxic (IC50, 140.19 ± 13.10 µg/mL) while ZnO_N is the most cytotoxic for HEP-G2 and BEAS-2B (IC₅₀, 51.27 ± 4.72 and 26.91 ± 3.21 µg/mL). All treatments change the morphology of erythrocytes to low concentrations (25 µg/mL). Therefore the MG load benefits the biological impact of ZnO.

近年来，金属氧化物作为封装基质已被研究，很少有研究在不同前体之间形成这种类型的纳米材料产生影响。在本文中，我们比较了其作为芒果苷（MG）纳米胶囊的能力。植物化学，由于其丰富的生物学特性而被研究，例如抗炎，抗增殖等；用硝酸锌和乙酸锌合成纳米颗粒（NP）。结果显示与前体相关的ZnO形态发生了变化，但是与抗拓扑异构酶活性相关的任何处理之间均没有显着差异，但是ZnO _A从统计学上讲，-MG是最好的治疗方法，与COX-I（68.02±2.14％）相比，COX-II前列腺素（97.38±7.09％）的产生比例减少（p <0.05）有显着差异（p <0.05），但未考虑选择性治疗此外的ZnO_甲-MG证明是至少肝毒性（IC50，140.19±13.10微克/毫升），而氧化锌_ñ是最细胞毒性对HEP-G2和BEAS-2B（IC ₅₀，51.27±4.72 26.91和3.21±微克/毫升）。所有处理都将红细胞的形态改变为低浓度（25 µg / mL）。因此，MG负载有益于ZnO的生物学影响。